GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Skin Quality · Facial dehydration / dry skin

PN PDRN injection with HA evidence for Facial dehydration / dry skin

C 46.3 / 100 Insufficient 0 RCT/meta · 1 clinical/observational · 0 case · 1 total
Early-stage evidence

This is an early evidence stage based mainly on observational studies and case reports. Use it as supplementary reference, and follow your doctor's judgment for treatment decisions.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Median year 2026 Last 5 years 100% Positive results 100%

Known in Korea as

리쥬란 HB

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier2 Midface volumization and skin quality enhancement with a hyaluronic acid-polynucleotide hybrid filler: a 24-week prospective open-label study. The Journal of dermatological treatment · 2026 · PMID 41626640

Abstract summary (English) BACKGROUND: Facial aging is characterized by midface volume loss from structural and dermal atrophy. OBJECTIVES: To evaluate the efficacy and safety of a hyaluronic acid-polynucleotide (HA-PN) hybrid filler for temporary restoration of anteromedial cheek volume. METHODS: In this single-center, open-label trial, 15 adults with moderate-to-severe anteromedial cheek volume loss (Mid-Face Volume Deficit Scale [MFVDS]...

Journal Article, Clinical Trial

View on PubMed

Suggested interpretation

Limited evidence

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