Skin Quality · Photodamaged skin / texture
PN PDRN injection evidence for Photodamaged skin / texture
There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.
Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.
Includes meta-analysis/SR Median year 2024 Last 5 years 76% Positive results 41% Negative results 4 Korea/Asia 6
Known in Korea as
Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.
Key papers
tier1 Efficacy of Ionization-Adjusted PN Filler in Minimizing Injection Pain: A Randomized, Patient-Blinded, Split-Face Study.
Abstract summary (English) Polynucleotide (PN) fillers are widely used for skin rejuvenation due to their regenerative properties; however, injection-related pain remains a major drawback. This randomized, patient-blinded, split-face study evaluated a novel "ionization-adjusted" PN filler with modified pH and ionic strength designed to reduce injection pain without compromising efficacy. Fifteen participants received 1 mL of conventional PN...
Journal Article, Randomized Controlled Trial
View on PubMedtier1 The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review.
Abstract summary (English) BACKGROUND: Polynucleotides (PN), popular in biorevitalization, show promise in the current sphere of esthetic medicine due to their regenerative properties, previously used in wound healing. Currently, research investigates their use in esthetic medicine. The aim of this review was to synthesize the existing literature, focusing on the effectiveness of PN in esthetic medicine, which is concentrated on skin...
Journal Article, Systematic Review
View on PubMedtier1 A Randomized, Participant- and Evaluator-Blinded, Matched-Pair, Prospective Study Comparing the Safety and Efficacy Between Polycaprolactone and Polynucleotide Fillers in the Correction of Crow's Feet.
Abstract summary (English) BACKGROUND: Dermal fillers have gained widespread popularity for facial cosmetic enhancement and anti-aging treatments. Recently, polycaprolactone (PCL) and polynucleotides (PN) fillers have emerged as promising options owing to their safety and long-lasting effects. OBJECTIVES: This study aimed to compare the efficacy and safety of a novel PCL-based dermal filler (DLMR01) with purified PN filler (RJR: Rejuran) in...
Journal Article, Randomized Controlled Trial, Comparative Study, Retracted Publication
View on PubMedtier1 Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial.
Abstract summary (English) BACKGROUND: Filler injection has become an extremely popular method for facial skin rejuvenation, including the periorbital area. In the recent years, new polynucleotide (PN)-containing filler products have been used for esthetic purposes. AIM: We aimed to investigate the efficacy and safety of PN filler injection in the periorbital area.
Journal Article, Randomized Controlled Trial
View on PubMedtier1 A randomized, patient/evaluator-blinded, split-face study to compare the efficacy and safety of polycaprolactone and polynucleotide fillers in the correction of crow's feet: The latest biostimulatory dermal filler for crow's feet.
Abstract summary (English) BACKGROUND: No data on the clinical results and safety profiles of the polycaprolactone (PCL) -based dermal filler for crow's feet correction have been published. AIMS: This study was designed to compare the efficacy and safety of a novel PCL-based dermal filler, DLMR01, with that of RJR, a purified polynucleotide dermal filler. PATIENTS/METHODS: A total of 30 subjects with symmetric crow's feet of 2-4 points on the...
Journal Article, Randomized Controlled Trial
View on PubMedtier1 A phase III, randomized, double-blind, matched-pairs, active-controlled clinical trial and preclinical animal study to compare the durability, efficacy and safety between polynucleotide filler and hyaluronic acid filler in the correction of crow's feet: a new concept of regenerative filler.
Abstract summary (English) The Rejuran® is a new filler product made from purified polynucleotides. Here we present data from an animal study and a clinical trial to examine the durability, efficacy and safety of the Rejuran® on crow's feet. For the animal study, 25 mice were divided into three groups: Group 1 received phosphate buffered saline (PBS); Group 2 were treated with Yvoire®; and Group 3 were treated with Rejuran®.
Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Retracted Publication
View on PubMedtier2 Midface volumization and skin quality enhancement with a hyaluronic acid-polynucleotide hybrid filler: a 24-week prospective open-label study.
Abstract summary (English) BACKGROUND: Facial aging is characterized by midface volume loss from structural and dermal atrophy. OBJECTIVES: To evaluate the efficacy and safety of a hyaluronic acid-polynucleotide (HA-PN) hybrid filler for temporary restoration of anteromedial cheek volume. METHODS: In this single-center, open-label trial, 15 adults with moderate-to-severe anteromedial cheek volume loss (Mid-Face Volume Deficit Scale [MFVDS]...
Journal Article, Clinical Trial
View on PubMedtier2 Prospective Observational Study of Polynucleotide Injections for Periorbital Rhytides.
Abstract summary (English) INTRODUCTION: Polynucleotides (PN), derived from salmon sperm DNA, are highly purified DNA fragments with reported tissue-repair and anti-inflammatory properties mediated through adenosine A2A receptor activation. These agents have been increasingly used in aesthetic dermatology for skin rejuvenation and scar treatment. This study aimed to evaluate longitudinal changes in periorbital appearance and patient-reported...
Journal Article, Observational Study
View on PubMedtier2 Therapeutic Performance of Needle Injection Versus Needle-Free Jet Injector System for Polynucleotide Filler in Skin Rejuvenation.
Abstract summary (English) BACKGROUND: Polynucleotide (PN) filler often causes pain and can lead to delivery inaccuracies when applied via intradermal injection using a traditional needle. AIMS: To evaluate the efficacy of treatment and the pain during the procedure using conventional needle injection versus a needle-free jet system for intradermal PN filler application. METHODS: In this split-face clinical trial, 10 Korean subjects were...
Journal Article, Comparative Study
View on PubMedtier0_review Skin boosters: Definitions and varied classifications.
Abstract summary (English) BACKGROUND: The concept of "skin boosters" has evolved, marking a shift from traditional uses of hyaluronic acid (HA) fillers primarily for augmenting skin volume to a more diverse application aimed at improving dermal conditions. Restylane Vital and other HA fillers have been repurposed to combat skin aging and wrinkles by delivering HA directly to the dermis. OBJECTIVES: This review aims to define the term "skin...
Journal Article, Review, Retracted Publication
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