Skin Quality · Periorbital fine lines / skin quality
PN PDRN injection evidence for Periorbital fine lines / skin quality
There is not yet enough PubMed evidence for this combination. The procedure exists, but research on this indication may be scarce.
Grade is an expert appraisal of the actual studies — their design, quality and on-topic relevance — while direction is a separate signal showing how those studies assess effectiveness.
Median year 2026 Last 5 years 100% Korea/Asia 1
Known in Korea as
Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.
Key papers
tier2 Prospective Observational Study of Polynucleotide Injections for Periorbital Rhytides.
Abstract summary (English) INTRODUCTION: Polynucleotides (PN), derived from salmon sperm DNA, are highly purified DNA fragments with reported tissue-repair and anti-inflammatory properties mediated through adenosine A2A receptor activation. These agents have been increasingly used in aesthetic dermatology for skin rejuvenation and scar treatment. This study aimed to evaluate longitudinal changes in periorbital appearance and patient-reported...
Journal Article, Observational Study
View on PubMedtier_other A survey on the cosmetic use of injectable polynucleotide: The pattern of practice among Korean Dermatologists.
Abstract summary (English) BACKGROUND: Skin boosters denote injectables that promote global improvement of the skin which includes skin texture, elasticity, hydration, and overall appearance. Polynucleotide (PN) products have become popular, but there is surprisingly little guidance on their use. We aimed to maximize the safety and efficacy of injectable PN by providing information on their pattern of practice among board-certified...
Journal Article
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