GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Volume / Contour · Nasolabial fold

Pdo PCL PLLA thread lifting evidence for Nasolabial fold

C 40.4 / 100 Supported 0 RCT/meta · 2 clinical/observational · 4 case · 15 total
Early-stage evidence

This is an early evidence stage based mainly on observational studies and case reports. Use it as supplementary reference, and follow your doctor's judgment for treatment decisions.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Median year 2020 Last 5 years 47% Positive results 67% Korea/Asia 4

Known in Korea as

돌기실모노실민트실압토스잼버실LSCO아이쓰레드맞춤 실리프팅실루엣 Fit실루엣 소프트

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier2 Nasolabial fold correction through cheek volume loss restoration versus thread lifting: a comparative study. Archives of dermatological research · 2020 · PMID 31898756

Abstract summary (English) Nasolabial folds are caused by loss of deep fat and subsequent loss of muscle contour in the midface, leading to sagging which forms cosmetic issues in some cases when they are otherwise overly pronounced. Various treatment procedures have been developed to reduce their appearance. The objective of this study is to compare the efficacy of hyaluronic acid (HA) cheek fillers injection and thread lifting in improving...

Comparative Study, Journal Article

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tier2 Stimulation of collagenesis by poly-L-lactic acid (PLLA) and -glycolide polymer (PLGA)-containing absorbable suspension suture and parallel sustained clinical benefit. Journal of cosmetic dermatology · 2020 · PMID 32167231

Abstract summary (English) BACKGROUND: Though the collagen-stimulating capacity of poly-L-lactic acid (PLLA) is well established, no data are available on collagen stimulation by the PLLA/PLGA within absorbable suspension sutures used for tissue repositioning. AIMS: To characterize collagen stimulation by absorbable suspension sutures through examination of patient biopsies and assess severity of nasolabial folds (NLF) over time....

Clinical Trial, Journal Article

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tier0_review Anatomical-Based Diagnosis and Filler Injection Techniques: Nasolabial Folds. The Journal of craniofacial surgery · 2025 · PMID 40900149

Abstract summary (English) Nasolabial folds significantly impact facial appearance and are a common aesthetic concern. This article reviews anatomic considerations and filler injection techniques for treating these folds, with a focus on the Korean population. The dermal filler used in this study is Maili hyaluronic acid filler (Sinclair Pharma), derived from a novel proprietary manufacturing technology known as OxiFree™ technology (Kylane...

Journal Article, Review

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tier0_review Why Do Nasolabial Folds Appear? Exploring the Anatomical Perspectives and the Role of Thread-Based Interventions. Diagnostics (Basel, Switzerland) · 2024 · PMID 38611629

Abstract summary (English) The classification of nasolabial folds into three types, each with distinct causative factors and mechanisms, is explored. Age-related changes in facial skin and connective tissues are examined in detail, revealing variations across different facial regions due to variances in tissue firmness and thickness. The innovative 'Reverse Technique,' involving cog threads to enhance tissue traction and effectiveness in...

Journal Article, Review

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tier3 Filler Injection Techniques and Ultrasound Observations: Ultrasound-Based Classification of Volume Deficiency in Nasolabial Folds. Aesthetic plastic surgery · 2025 · PMID 41120613

Abstract summary (English) BACKGROUND: Nasolabial folds (NLFs) are a hallmark of facial ageing, and precise correction requires detailed anatomical and vascular mapping. High-resolution ultrasound offers real-time visualisation of soft-tissue layers, filler distribution, and vascular anatomy, enabling safer and more targeted injection. This study integrates ultrasound into the aetiologic classification and treatment algorithm for NLF...

Journal Article, Comment

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tier3 Reverse and antegrade vector thread lifting techniques: Correcting nasolabial and marionette lines. Journal of cosmetic dermatology · 2024 · PMID 39107950

Abstract summary (English) BACKGROUND: This study evaluates the efficacy of reverse and antegrade thread lifting vectors in conjunction with thread selection for correcting nasolabial folds and marionette lines, aiming to enhance treatment precision and effectiveness. METHODS: Three female patients aged 43, 48, and 53, presenting with primary concerns regarding nasolabial folds, underwent distinct treatment regimens utilizing various types of...

Journal Article, Case Reports

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tier3 An innovative thread-lift technique for facial rejuvenation and complication management: A case report. Medicine · 2018 · PMID 29794731

Abstract summary (English) RATIONALE: Aging of face is an unavoidable process. Traditional procedures for facial rejuvenation have multiple disadvantages. In this case report, we used an innovative technique combining thread lift with small incision rhytidectomy for facial rejuvenation.

Case Reports, Journal Article

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tier_other Prospective Study of Three-Dimensional Bi-directional Barbed Threads for Midface and Nasolabial Fold Rejuvenation. Aesthetic plastic surgery · 2025 · PMID 41145860

Abstract summary (English) BACKGROUND: Thread lifting is a minimally invasive procedure using absorbable sutures like polydioxanone (PDO) to provide immediate lifting and stimulate collagen for long-term skin rejuvenation. This prospective study evaluates the safety and efficacy of Croquis® Barbed Cutting PDO threads, featuring a unique 3D bi-directional barb design, in enhancing facial lifting outcomes. METHODS: Thirty participants with...

Journal Article

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tier_other Anatomical Considerations and Technique for Nasolabial Fold Thread Lifting. Plastic and reconstructive surgery. Global open · 2025 · PMID 41040895

Abstract summary (English) This review presents a comprehensive analysis of nasolabial fold classification and correction using thread-lifting techniques. Three distinct types of nasolabial folds are identified: those caused by paranasal volume deficiency, differential tissue laxity, and muscular insertions. The study emphasized the importance of Lore fascia as a key anatomical landmark and optimal adhesion point for thread placement,...

Journal Article

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tier_other Patient Satisfaction with Absorbable Anchoring Facial Threads. Facial plastic surgery : FPS · 2021 · PMID 33621988

Abstract summary (English) This study aimed to evaluate satisfaction in terms of facial appearance, quality of life, and adverse effects in patients undergoing the facial thread lifting procedure using the absorbable facial threads anchored on the superficial and deep temporal fascias. The charts of patients for whom facial anchored thread lifting was performed using absorbable threads between February 2017 and September 2019 were reviewed....

Journal Article

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Suggested interpretation

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