LED phototherapy evidence for Photodamaged skin / texture

Abstract summary (English) This study compared the efficacy of 570 nm and 590 nm yellow light, combined with red light and infrared LED phototherapy, in treating facial skin photoaging. Thirty patients with skin photoaging were enrolled between December 2024 and January 2025 and randomly assigned to two groups: the 570 nm combined LED group (hereafter referred to as the 570 group) and the 590 nm combined LED group (hereafter referred to as...

Journal Article, Randomized Controlled Trial

Abstract summary (English) Objective: This study aimed to evaluate red and amber light-emitting diode protocols for facial rejuvenation at the same light dose. Background: The demand for minimally invasive cosmetic procedures to address skin aging has grown throughout the world. In vitro red and amber photobiomodulation (PBM) has been shown to improve collagen synthesis.

Randomized Controlled Trial, Journal Article

Abstract summary (English) BACKGROUND: Light-emitting diodes (LEDs) may be used as an activating light source for photosensitizers in photodynamic therapy (PDT), a form of noninvasive phototherapy. Photodynamic therapy for aesthetic dermatologic conditions has demonstrated skin rejuvenating effects. OBJECTIVE: To evaluate the safety and efficacy of PDT using LEDs to treat aesthetic dermatologic conditions including photoaged skin, scarring,...

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: Skin is the organ most extensively exposed to light of a broad range of wavelengths. Several studies have reported that skin expresses photoreceptive molecules called opsins. However, the identity and functional role of opsins in the human skin remain elusive.

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: Topical photodynamic therapy (PDT) is an approved treatment for superficial nonmelanoma skin cancers. To enhance photosensitizer penetration into the epidermis, microneedling (MN) devices or ablative carbon dioxide lasers are combined with PDT. OBJECTIVES: To compare the efficacy and safety of MN-assisted PDT with that of conventional PDT in human skin field cancerization.

Comparative Study, Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Photodynamic therapy (PDT) is an option for skin rejuvenation. Although many studies report clinical improvement with PDT in photodamaged skin, histologic and morphometric evidence is not documented in most cases. OBJECTIVE: To evaluate clinical and histopathologic changes induced by methyl aminolevulinate (MAL)-PDT and to morphometrically quantify collagen and elastic fibers in skin remodeling induced...

Journal Article, Randomized Controlled Trial

Abstract summary (English) OBJECTIVES: To evaluate the clinical efficacy and ultrastructural changes in photodamaged skin after combined 633-nm and 830-nm light-emitting diode (LED) treatments. METHODS: Thirty-six subjects received 9 LED treatments over the course of 5 weeks and were subsequently evaluated for final clinical improvement 12 weeks after treatment. Five subjects were also biopsied to determine the ultrastuctural posttreatment...

Journal Article, Multicenter Study, Randomized Controlled Trial

Abstract summary (English) BACKGROUND AND OBJECTIVES: Photomodulation has been described as a process which modifies cell activity using light sources without thermal effect. The objective of this study was to investigate the use of a non-thermal low dose light emitting diode (LED) array for improving the appearance of photoaged subjects. STUDY DESIGN/MATERIALS AND METHODS: This prospective study investigated a random cohort of patients (N =...

Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

Abstract summary (English) Minimally ablative fractional laser devices have gained acceptance as a preferred method for skin resurfacing. Notable improvements in facial rhytides, photodamage, acne scarring, and skin laxity have been reported. The aim of the present work was to compare how different CO(2) laser fluences, by modulating the secretory pathway of cytokines, are able to influence the wound-healing process, and how these fluences...

Clinical Trial, Journal Article

Abstract summary (English) BACKGROUND: Light-emitting diode (LED) therapy is an increasingly popular methodology for the treatment of sun damage. Combination use of light wavelengths reported to stimulate collagen synthesis and accelerate fibroblast-myofibroblast transformation may display a composite rejuvenative effect. OBJECTIVE: To clinically assess reduction in sun damage signs following a 5-week course of LED therapy and to assess...

Clinical Trial, Journal Article