Skin Quality · Photodamaged skin / texture
HA skin booster evidence for Photodamaged skin / texture
This is an early evidence stage based mainly on observational studies and case reports. Use it as supplementary reference, and follow your doctor's judgment for treatment decisions.
Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.
Median year 2023 Last 5 years 70% Positive results 70% Negative results 1 Korea/Asia 1
Known in Korea as
Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.
Key papers
tier1 A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study.
Abstract summary (English) BACKGROUND: NCTF®135HA is a bio-revitalizing solution containing hyaluronic acid designed to compensate for skin dehydration, fatigue, and fine wrinkles associated with endogenous and environmental aging. METHODS: We conducted a randomized, active-controlled study to evaluate the efficacy and tolerability of NCTF®135HA injections on the face (crow's feet), neck, and décolleté regions. Subjects were randomly assigned...
Randomized Controlled Trial, Multicenter Study, Journal Article
View on PubMedtier1 Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial.
Abstract summary (English) BACKGROUND: Filler injection has become an extremely popular method for facial skin rejuvenation, including the periorbital area. In the recent years, new polynucleotide (PN)-containing filler products have been used for esthetic purposes. AIM: We aimed to investigate the efficacy and safety of PN filler injection in the periorbital area.
Journal Article, Randomized Controlled Trial
View on PubMedtier2 Clinical and Biometric Assessment of a Hyaluronic Acid-Based Skin Booster for Face, Neck and Décolleté Rejuvenation: A Prospective Study.
Abstract summary (English) BACKGROUND: Hyaluronic acid based skinboosters present a low rheological profile that allows for even distribution throughout the dermis and focuses on improving skin's overall quality. Scientific efforts are ongoing with the aim of developing optimal skinboosters that meet specific clinical requirements and satisfactory overall results. OBJECTIVE: Assess clinically the efficacy and safety of a newly developed...
Journal Article, Clinical Trial
View on PubMedtier0_review Current Concepts in the Use of Small-Particle Hyaluronic Acid.
Abstract summary (English) BACKGROUND: Soft-tissue augmentation with hyaluronic acid (HA) fillers has become one of the most popular cosmetic procedures performed. HA fillers represent safe and commonly used fillers. Several different HA fillers are available.
Journal Article, Review
View on PubMedtier3 Persistent Nodules on Necklines Following Hyaluronic Acid Filler: A Case Report.
Abstract summary (English) BACKGROUND: Necklines are a common complaint in patients as they are a sign of aging. Hyaluronic acid (HA) fillers are widely used to address volume loss and linear depressions. HA fillers are safe, effective, and versatile, but their use for necklines is not well-documented in the literature.
Case Reports, Journal Article
View on PubMedtier3 Microscopic and clinical evidence of the degradation of polydioxanone lifting threads in the presence of hyaluronic acid: a case report.
Abstract summary (English) We present the case of a female patient with complications from superficial implantation of polydioxanone spiculated threads in the facial middle third. The manifestations were edema, ecchymosis, superficial palpation of the thread and skin plication. For the treatment we propose a novel protocol of clinical degradation of polydioxanone threads, using hyaluronic acid injecting it into the implantation area of the...
Case Reports, Journal Article
View on PubMedtier_other Combined Use of Relabotulinum Toxin A and NASHA Gel Skinbooster for Rejuvenation of the Upper Third of the Face.
Abstract summary (English) BACKGROUND: Aging of the upper third of the face is characterized by dynamic forehead wrinkles and volume loss in the temporal region, resulting in a fatigued and aged appearance. Addressing both muscle hyperactivity and soft tissue atrophy is essential for effective rejuvenation. OBJECTIVE: To evaluate a combined injectable treatment protocol using Relabotulinum Toxin A for frontalis muscle modulation and...
Journal Article
View on PubMedtier_other Skin-Booster Injection on the Left and Right Sides: Which Side Is More Painful?
Abstract summary (English) BACKGROUND: Skin booster injections using agents such as hyaluronic acid and poly-D,L-lactic acid (PDLLA, Juvelook, VAIM GLOBAL Inc., Korea) are commonly used to enhance skin texture and reduce wrinkles. However, pain during injection remains a limiting factor in patient compliance and comfort. OBJECTIVE: To evaluate whether there is a difference in perceived pain between the left and right facial sides during PDLLA...
Journal Article
View on PubMedtier_other The efficacy of intradermal hyaluronic acid filler as a skin quality booster: A prospective, single-center, single-arm pilot study.
Abstract summary (English) BACKGROUND: The use of "skin boosters" comprised of hyaluronic acid (HA)-based fillers to improve skin quality has gained popularity recently, especially in individuals interested in skin rejuvenation. AIM: This study aimed to evaluate the efficacy and safety of intradermal micropuncture injections of HA-based gel filler combined with lidocaine (BYRYZN® SKINBOOSTER HA, ACROSS Co., Ltd., Gangwon-do, Korea)....
Journal Article
View on PubMedtier_other High-velocity pneumatic injection of non-crosslinked hyaluronic acid for skin regeneration and scar remodeling: A retrospective analysis of 115 patients.
Abstract summary (English) BACKGROUND: Pneumatic-assisted high velocity jet injections are an alternative method for intradermal delivery of hyaluronic acid (HA) and demonstrated efficacy in dermal thickening and scar remodeling with minimal side effects. AIMS: We aimed to investigate the clinical efficacy comparing non-crosslinked HA (NCL-HA) and crosslinked HA (CL-HA) for aesthetic skin concerns. METHODS: We retrospectively analyzed charts...
Journal Article
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