GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Volume / Contour · Prejowl sulcus

HA filler crosslinked evidence for Prejowl sulcus

C 37.1 / 100 Mixed evidence 1 RCT/meta · 0 clinical/observational · 1 case · 11 total
Early-stage evidence

This is an early evidence stage based mainly on observational studies and case reports. Use it as supplementary reference, and follow your doctor's judgment for treatment decisions.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Median year 2021 Last 5 years 55% Positive results 18% Negative results 1 Korea/Asia 2

Known in Korea as

필러라풀렌리쥬필리즈네미라콜쥬비덤뉴라미스레스틸렌리쥬비엘바디필러

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Hyaluronic Acid Filler VYC-25L for Jawline Restoration Yields High Satisfaction, Improved Jawline Measurements, and Sustained Effectiveness Across Skin Types, Age, and Gender for up to 12 Months. Aesthetic surgery journal · 2024 · PMID 39141784

Abstract summary (English) BACKGROUND: A randomized study previously reported demonstration of the safety and efficacy of hyaluronic acid filler VYC-25L for restoring jawline definition. OBJECTIVES: The aim of this study was to evaluate patient-reported outcomes (PROs), objective changes in jawline profile, and safety and effectiveness measures by Fitzpatrick skin phototype (FST), gender, and age following VYC-25L treatment. METHODS: Adults...

Journal Article, Randomized Controlled Trial

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tier0_review Anatomical-based diagnosis and filler injection techniques: marionette line (static labiomandibular fold). The Journal of dermatological treatment · 2025 · PMID 39894451

Abstract summary (English) PURPOSE: Marionette lines, also known as static labiomandibular folds, are common age-related perioral wrinkles that impact facial aesthetics, particularly in Asian populations. This article aims to examine the anatomical basis, etiology, and filler injection techniques used for treating marionette lines. MATERIALS AND METHODS: The study reviews anatomical studies and clinical practices related to marionette lines.

Journal Article, Review

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tier0_review The Role of Toxins and Fillers in Optimizing Perioral Rejuvenation. Facial plastic surgery : FPS · 2025 · PMID 40550475

Abstract summary (English) Neurotoxins and fillers have become increasingly popular for restoring age-related changes in the perioral region. This review examines their roles in optimizing perioral rejuvenation.The perioral region composes the lower third and middle three-fifths of the face. It includes the lips, surrounding perioral skin, chin, muscles of facial expression, maxilla, and mandible.

Journal Article, Review

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tier0_review Nonsurgical Chin and Prejowl Modification. Facial plastic surgery : FPS · 2025 · PMID 40389235

Abstract summary (English) The chin and prejowl areas play a critical role in the perception of facial harmony. This paper explores nonsurgical approaches for chin and prejowl rejuvenation, emphasizing anatomy, aesthetic concerns, and the plethora of available treatment modalities.Bony landmarks such as the pogonion, menton, and mental protuberance define the chin, while muscles like the mentalis, depressor anguli oris (DAO), and depressor...

Journal Article, Review

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tier0_review Augmenting the Prejowl: Deciding between Fat, Fillers, and Implants. Facial plastic surgery : FPS · 2016 · PMID 27680523

Abstract summary (English) The prejowl sulcus is a complex anatomic structure that results from several age-related changes in the lower face. These changes include the localized atrophy of a segment of the mandible inferior to the mental foreman, fat atrophy, and dehiscence and laxity of the ligamentous and muscular components of the region. The correction of the prejowl sulcus is rarely accomplished through rhytidectomy alone.

Journal Article, Review

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tier0_review Lower Face: Clinical Anatomy and Regional Approaches with Injectable Fillers. Plastic and reconstructive surgery · 2015 · PMID 26441104

Abstract summary (English) The use of injectable fillers enables facial sculpting through treatment of volume depletion and modeling of facial contours. Injectable fillers are among the most frequently performed minimally invasive cosmetic procedures.However, treatment of the lower third of the face can be challenging and requires expertise in facial anatomy. In this article, the authors provide a comprehensive review of the anatomy of the...

Journal Article, Review

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tier3 Composite Facial Volumization With Calcium Hydroxylapatite (CaHA) for the Treatment of Aging. Aesthetic surgery journal · 2018 · PMID 29897520

Abstract summary (English) Paradigms in the treatment of aging have evolved to address volume loss as a central and primary hallmark of the aging face. The concept of "composite volumization" was recently proposed by Dr. Z.

Case Reports, Journal Article

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tier_other Target-Specific Sandwich Technique: Facial rejuvenation leveraging CPM technology. Journal of cosmetic dermatology · 2021 · PMID 34255904

Abstract summary (English) Injectable rejuvenation treatments used in Caucasians might not always suit Asians as the visible signs of aging manifest differently, underscoring a need for Asian-specific strategies that correct underlying structural deficiencies and cumulative age-related changes. The presented Target-Specific Sandwich Technique (TSST) aims to simultaneously restore, rejuvenate, and enhance faces through the distribution of...

Journal Article

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tier_other Quantitative Analysis of the Lifting Effect of Facial Soft-Tissue Filler Injections. Plastic and reconstructive surgery · 2021 · PMID 33890889

Abstract summary (English) BACKGROUND: Although injectable soft-tissue fillers are frequently used for facial rejuvenation, there is a dearth of objective data evaluating the tissue-lifting effects. Current practices for efficacy evaluation include some subjectivity. This study seeks to evaluate the lifting effects of facial soft-tissue fillers in a quantifiable, objective setting.

Journal Article

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tier_other Open-Label, Post-Marketing Study to Evaluate the Performance and Safety of Calcium Hydroxylapatite With Integral Lidocaine to Correct Facial Volume Loss. Journal of drugs in dermatology : JDD · 2019 · PMID 30681803

Abstract summary (English) Background: Calcium hydroxylapatite (CaHA, Radiesse®) with integral 0.3% lidocaine (CaHA(+)) has recently been approved for use in aesthetic medicine. This study assessed the performance of CaHA(+) in subjects undergoing treatment for facial volume loss and evaluated subject and physician satisfaction. Methods: In a prospective, open-label, post-marketing study, 25 women seeking treatment for age-related facial...

Journal Article

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Suggested interpretation

Limited evidence

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