HA filler crosslinked evidence for Chin augmentation

Abstract summary (English) BACKGROUND: Dermal fillers are a primary treatment for chin retrusion. However, current options have limitations in longevity and biomechanical properties. OBJECTIVES: The aim of this study was to evaluate the efficacy and safety of a novel filler, comprised of polyvinyl alcohol (PVA) microspheres suspended in hyaluronic acid (PVA-HA), for chin augmentation.

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: The chin is a crucial facial feature for overall attractiveness. Lower third imbalance can lead to signs of premature aging and loss of jawline contour. Effective chin augmentation with hyaluronic acid fillers has been demonstrated in the literature.

Journal Article, Randomized Controlled Trial, Comparative Study

Abstract summary (English) BACKGROUND AND AIM: The present study aimed to evaluate the effectiveness of the two-three-point injection technique using hyaluronic acid fillers to increase chin volume. METHOD: The present study included three RCT and three cohort studies of international databases, PubMed, Scopus, Web of Science, and Embase using relevant keywords until June 2025. The statistical analysis was performed with Stata/MP.v17 as fixed...

Journal Article, Systematic Review, Meta-Analysis, Review

Abstract summary (English) BACKGROUND: Individuals with chin retrusion may seek chin and lower jawline aesthetic enhancement. OBJECTIVES: To evaluate VYC-25L (Juvéderm Volux XC; Allergan Aesthetics, an AbbVie company), a lidocaine-containing injectable hyaluronic acid dermal filler, for chin retrusion correction. METHODS: In this prospective, Phase 3, multicenter study (NCT04559984), Chinese adults with moderate-to-severe chin retrusion on...

Journal Article, Multicenter Study, Randomized Controlled Trial, Clinical Trial, Phase III

Abstract summary (English) BACKGROUND: MaiLi-E is a lidocaine-containing cross-linked sodium hyaluronate gel for dermal filling. This prospective, multicenter, randomized, delayed-treatment controlled, evaluator-blinded clinical trial aims to evaluate the efficacy and safety of MaiLi-E for chin augmentation. METHODS: Participants with mild-to-moderate-severe chin retrusion were enrolled and randomized (2:1) to receive MaiLi-E at study onset...

Journal Article, Randomized Controlled Trial, Multicenter Study, Research Support, Non-U.S. Gov't

Abstract summary (English) BACKGROUND: Hyamax® Monophasic Volumizer Dermal Fillers is a newly designed hyaluronic acid soft tissue filler for chin augmentation. METHODS: A prospective, single-center, evaluator-blinded, randomized controlled study was designed to evaluate the effectiveness and safety of Hyamax® Volumizer in the correction of chin retrusion in the 18-55-year-old Chinese population for 12 months after treatment. Participants...

Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

Abstract summary (English) BACKGROUND: The chin significantly influences facial aesthetics, contributing to the overall balance and harmony of the face. This study aimed to assess the effectiveness of the hyaluronic acid filler Hyamax® Volumizer for chin augmentation and correction of chin retrusion compared to a no-treatment control. METHODS: Participants aged 18-55 years with mild to moderate chin retrusion were randomized in a 3:1 ratio to...

Journal Article, Randomized Controlled Trial, Multicenter Study

Abstract summary (English) BACKGROUND: Hyaluronic acid (HA) has already been widely administered for chin augmentation. Patients with chin retrusion frequently present with increased chin hypertonia. Monotherapy with HA falls short in addressing the multifaceted cosmetic concerns associated with chin retrusion.

Randomized Controlled Trial, Journal Article, Research Support, Non-U.S. Gov't

Abstract summary (English) BACKGROUND: In an evaluator-blinded, randomized controlled trial, the hyaluronic acid soft-tissue filler VYC-20L injectable gel was safe and effective for correcting volume deficits and retrusion in the chin. OBJECTIVES: The objective of this subanalysis was to compare responder rates obtained with photographic vs live assessments. METHODS: Participants were randomized 3:1 to VYC-20L treatment or a 6-month,...

Randomized Controlled Trial, Journal Article, Research Support, Non-U.S. Gov't

Abstract summary (English) BACKGROUND: A hyaluronic acid (HA) filler intended for non-surgical improvement of chin appearance should ideally be of high strength/firmness (high G') to allow for deep injections on the bone. HASHA (Restylane Shaype) is a new hyaluronic acid (HA) injectable with high G' and high HA concentration (25 mg/mL), engineered by the new NASHA-HD (High Definition) technology. HASHA is suitable to be placed periosteally,...

Randomized Controlled Trial, Journal Article