Skin Quality · Photodamaged skin / texture
Fractional picosecond resurfacing evidence for Photodamaged skin / texture
There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.
Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.
Includes meta-analysis/SR Median year 2022 Last 5 years 65% Positive results 56% Negative results 5 Korea/Asia 13
Known in Korea as
Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.
Key papers
tier1 Comparative Study of a 1064 nm Fractional Picosecond Laser Versus Intense Pulsed Light in Facial Rejuvenation: A Prospective Randomized Trial.
Abstract summary (English) BACKGROUND AND OBJECTIVES: Skin aging, characterized by wrinkles, pigment disorders, and enlarged pores, is driven primarily by photoaging. While a 1064 nm fractional picosecond laser shows efficacy in skin rejuvenation, comparative studies with intense pulsed light (IPL) remain limited. This randomized controlled trial (RCT) aimed to compare the efficacy and safety of the 1064 nm fractional picosecond laser with...
Journal Article, Randomized Controlled Trial, Comparative Study
View on PubMedtier1 Effect of the combination of long-pulse 1064 nm neodymium-doped yttrium aluminum garnet laser and picosecond 755 nm alexandrite laser with diffractive lens array on skin photoaging: a randomized, split-face multicenter clinical trial.
Abstract summary (English) To evaluate the efficacy and safety of the combination of the long-pulse 1064 nm neodymium-doped yttrium aluminum garnet (LP1064 nm) laser and picosecond 755 nm alexandrite (P755 nm) laser with a diffractive lens array (DLA) in improving skin photoaging. This prospective, randomized, split-face trial was conducted between April 2024 and February 2025 at two centers. A total of 22 healthy volunteers with facial...
Journal Article, Multicenter Study, Randomized Controlled Trial
View on PubMedtier1 Treatment of Solar Lentigines: A Systematic Review of Clinical Trials.
Abstract summary (English) BACKGROUND: Solar lentigines, resulting from chronic UV exposure, are early signs of photoaging and can significantly affect individuals. AIMS: This systematic review evaluates the efficacy, safety, and tolerability of treatments for solar lentigines in light of a lack of conclusive evidence regarding optimal therapy options. METHODS: A systematic search of PubMed/Medline, EMBASE, Cochrane Library, and...
Systematic Review, Journal Article
View on PubMedtier1 Comparison of Intense Pulsed Light With Nonablative Fractional Laser and Picosecond Alexandrite Laser With Diffractive Lens Array for Noninvasive Facial Rejuvenation.
Abstract summary (English) BACKGROUND: Both nonablative fractional (NAFL) laser combined with intense pulsed light (IPL) and picosecond alexandrite laser (PSAL) with diffractive lens array (DLA) have been documented for their efficacy in facial rejuvenation. OBJECTIVE: To observe the safety and efficacy of PSAL-DLA and IPL-NAFL in the rejuvenation of Chinese individuals. METHODS: Each subject (n = 18) received three treatments on half of...
Journal Article, Comparative Study, Randomized Controlled Trial
View on PubMedtier1 Three-Year Results of Facial Photoaging in Asian Patients After Alexandrite 755 nm Picosecond Laser With Diffractive Lens Array: A Split-Face, Single-Blinded, Randomized Controlled Comparison.
Abstract summary (English) BACKGROUND AND OBJECTIVE: The long-term efficacy of a picosecond alexandrite laser (PSAL) with a diffractive lens array (DLA) for the treatment of photoaging is absent. To observe the long-term efficacy of PSAL for the treatment of photoaging. STUDY DESIGN/MATERIALS AND METHODS: Each patient (n = 10) received 10 treatments at 2-week intervals.
Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
View on PubMedtier1 Prospective randomized controlled trial comparing treatment efficacy and tolerance of picosecond alexandrite laser with a diffractive lens array and triple combination cream in female asian patients with melasma.
Abstract summary (English) BACKGROUND: Recent evidence suggests melasma to be a photoaging disorder. Triple combination creams (TCC: fluocinolone acetonide 0.01%, hydroquinone 4% and tretinoin 0.05%) remain the gold standard treatment. Picosecond alexandrite laser treatment using a diffractive lens array (DLA) has been identified to be effective for improving photoaging conditions.
Comparative Study, Journal Article, Randomized Controlled Trial
View on PubMedtier1 A randomized, single-blind, study evaluating a 755-nm picosecond pulsed Alexandrite laser vs. a non-ablative 1927-nm fractionated thulium laser for the treatment of facial photopigmentation and aging.
Abstract summary (English) Background: Laser toning is one of the most popular strategies to treat facial photopigmentation and aging. Several laser modalities, including fractional non-ablative, Q-switched (QS) lasers and new generation picosecond lasers have been used for this indication. However, there is paucity of head to head comparisons of older generation of lasers with new ones.
Comparative Study, Journal Article, Randomized Controlled Trial
View on PubMedtier2 The Comparison of the Efficacy and Safety of Fractional 1064 nm Nd:YAG Picosecond Laser and Fractional Q-Switched 1064-nm Nd:YAG Laser in the Improvement of Photoaging: A Split-Face Study.
Abstract summary (English) BACKGROUND: Facial photoaging is a complex biological process influenced by both internal and external factors. It is characterized by wrinkles, enlarged pores, and rough skin. Despite various clinical treatments, they often have limited effectiveness, significant side effects, and extended recovery times.
Journal Article, Comparative Study
View on PubMedtier2 Study of a 532/1064 Fractional Picosecond Laser for Facial Rejuvenation.
Abstract summary (English) BACKGROUND AND OBJECTIVES: Picosecond (ps) fractional lasers create small wounds, presumably by laser-induced optical breakdown. We studied a ps fractional laser in the treatment of wrinkles and mottled pigment. MATERIALS AND METHODS: This was a single center, prospective, open-label clinical trial.
Clinical Trial, Journal Article
View on PubMedtier2 Paired facial treatment with 755nm picosecond laser with diffractive lens array and 1060nm laser lipolysis of the submentum: An open-label prospective trial.
Abstract summary (English) BACKGROUND: Performing multiple cosmetic treatments in a single session to target different aspects of facial rejuvenation is an effective regimen. Picosecond lasers with a fractionated handpiece can target fine lines, which can supplement submental fat reduction procedures. However, limited data exist on the safety and efficacy of single-session treatment strategies.
Clinical Trial, Journal Article
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