Skin Quality · Photodamaged skin / texture
Fractional laser resurfacing evidence for Photodamaged skin / texture
There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.
Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.
Includes meta-analysis/SR Median year 2016 Last 5 years 30% Positive results 63% Negative results 5 Korea/Asia 15
Known in Korea as
Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.
Key papers
tier1 Prospective, Split-Face Randomized Clinical Trial Comparing Non-ablative Fractional Laser for Periorbital Photoaging in Different Age Groups.
Abstract summary (English) BACKGROUND: The 1550 nm and 1565 nm non-ablative fractional lasers (NAFL) have recently been introduced as treatments for periorbital photoaging. This prospective, randomized split-face trial aimed to evaluate the safety and effectiveness of these NAFL treatments in addressing periorbital photoaging in Asian patients across various age groups. METHODS: Eighteen patients completed the study, with nine under 45 (Group...
Journal Article, Randomized Controlled Trial, Comparative Study
View on PubMedtier1 Comparative analysis of erbium: glass 1550 nm and combined erbium: YAG & Nd: YAG lasers for perioral rejuvenation: a prospective study.
Abstract summary (English) Perioral aging manifests as fine lines, wrinkles, and structural changes, often requiring specialized treatment. Although laser systems are widely used in facial rejuvenation, few studies directly compare their efficacy in perioral rejuvenation. This study evaluates and compares the efficacy and safety of two laser systems-Erbium: glass laser and Nd: YAG combined with Er: YAG laser-for perioral rejuvenation.
Journal Article, Comparative Study, Randomized Controlled Trial
View on PubMedtier1 A Multi-Component Reaction Peptide Augmenting the Anti-Aging Benefits of Non-Ablative Laser Procedure.
Abstract summary (English) BACKGROUND: Laser resurfacing is one of the most popular aesthetic procedures that address a wide range of skin conditions and overall skin rejuvenation. To reduce downtime and improve the clinical efficacy of the procedures, it is important to design post-procedure care routines to complement them. Towards fulfilling that consumer need, a peptide synthesized from multi-component reaction (MCP) has been developed.
Journal Article, Randomized Controlled Trial
View on PubMedtier1 Safety and efficacy of human platelet extract in skin recovery after fractional CO2 laser resurfacing of the face: A randomized, controlled, evaluator-blinded pilot study.
Abstract summary (English) BACKGROUND: Fractional carbon dioxide (CO2 ) laser resurfacing is used successfully for facial rejuvenation. Post procedure skincare is a variable that influences downtime caused by pain/tenderness, erythema, crusting, and bruising. AIMS: The primary objective of this pilot study was to demonstrate the benefits of human platelet extract (HPE) (plated)™ CALM Serum, a new topical cosmetic product, following...
Randomized Controlled Trial, Journal Article
View on PubMedtier1 Fractional microneedle radiofrequency device and fractional erbium-doped glass 1,565-nm device treatment of human facial photoaging: a prospective, split-face, random clinical trial.
Abstract summary (English) Microneedle fractional radiofrequency (MFR) and non-ablative 1565 nm fractional laser (NAFL) have recently been introduced as new techniques to address the growing concern of facial photoaging. In this prospective randomized split-face study, we wanted to compare the safety and efficacy of MFR with that of NAFL for the treatment of facial photoaging in Asian patients. Fifteen healthy Chinese patients were enrolled...
Journal Article, Randomized Controlled Trial
View on PubMedtier1 Low-fluence and low-density CO2 laser: histological analysis of collagen fiber changes in skin and its clinical repercussions in photorejuvenation.
Abstract summary (English) This study refers to clinical and histologic analysis of effects on photorejuvenation after one single treatment of fractional CO2 laser with low fluence and low density. To analyze histologically the quantitative variation of collagen fibers type I and III, elastic fibers, and epidermal thickness on D84, besides clinical evaluation of amount, length, thickness, and depth of periocular wrinkles during the same...
Journal Article, Randomized Controlled Trial
View on PubMedtier1 Treatment of periorbital wrinkles using thermo-mechanical fractional injury therapy versus fractional non-ablative 1565 nm laser: A comparative prospective, randomized, double-arm, controlled study.
Abstract summary (English) BACKGROUND: Non-ablative fractional laser is an effective modality for the treatment of periorbital wrinkling, one of the earliest signs of skin aging. Thermo-mechanical fractional injury (TMFI) therapy (Tixel®, Novoxel®, Israel) is an innovative technology that is now being used for facial skin rejuvenation. Our study compares the clinical results, side effects, and downtime profile between TMFI treatment and...
Case Reports, Randomized Controlled Trial, Journal Article
View on PubMedtier1 A randomized, split-face controlled trial on the safety and effects of microneedle fractional radiofrequency and fractional erbium-doped glass 1,565-nm laser therapies for baggy lower eyelids.
Abstract summary (English) UNLABELLED: The non-ablative fractional erbium-doped glass 1,565-nm laser (NAFL) and the microneedle fractional radiofrequency (MFR) procedures are effective treatments that enable periorbital skin rejuvenation. To compare the clinical effectiveness and side effects of MFR and the NAFL for baggy lower eyelids (BLEs) in the Chinese population. Fifteen Chinese subjects with BLEs received three split-face treatments on...
Journal Article, Randomized Controlled Trial
View on PubMedtier1 Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy.
Abstract summary (English) BACKGROUND: Recent advancements in laser-assisted drug delivery have emphasized the importance of post-laser use of active ingredients. AIMS: We evaluated the effect of topical post-laser treatment with adipocyte-derived stem cell-containing medium (ADSC-CM) in combination with niacinamide through a double-blind, randomized, vehicle-controlled study. PATIENTS/METHODS: Twenty-five patients with aging skin underwent...
Journal Article, Randomized Controlled Trial
View on PubMedtier1 Early and maintained application of the secretion of Cryptomphalus aspersa (SCA) 40% improves cutaneous healing after ablative fractional laser in skin aging.
Abstract summary (English) BACKGROUND: Ablative fractional laser generates a regulated skin damage, which secondarily improves skin aging. AIMS: The main objective of the present study was to figure out if the adverse effects induced by laser and the skin recovery could improve with the application of a cosmetic product based on the secretion of Cryptomphalus aspersa (SCA). PATIENTS/METHODS: A prospective double-blind controlled study with...
Journal Article, Randomized Controlled Trial
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