Exosome topical or injection evidence for Photodamaged skin / texture

Abstract summary (English) BACKGROUND: Microneedling combined with exosome therapy has growing clinical relevance in dermatology. This systematic review will critically evaluate current evidence on the combined use of microneedling and exosomes in a number of dermatological diseases. METHOD: A systematic literature search was conducted using terms related to exosomes and microneedling using 3 databases in accordance with the Preferred...

Systematic Review, Journal Article

Abstract summary (English) BACKGROUND: Needling radiofrequency (NRF) induces controlled dermal remodeling while preserving the epidermis. Rose stem cell-derived exosomes (RSCEs) possess regenerative and anti-inflammatory properties, but limited penetration restricts clinical utility. OBJECTIVES: To assess whether RSCEs applied immediately after NRF enhance improvement in wrinkles, texture, and pores in Asian patients.

Journal Article, Randomized Controlled Trial

Abstract summary (English) Exosomes have gained increasing attention in aesthetic medicine for their regenerative properties and role in skin and hair rejuvenation. By stimulating collagen production, delivering growth factors, and supporting follicle regeneration, they offer a novel, noninvasive approach to facial rejuvenation and hair growth. A systematic review and meta-analysis were conducted to evaluate the clinical efficacy of exosome...

Journal Article, Systematic Review, Meta-Analysis

Abstract summary (English) AIMS AND OBJECTIVES: This study aims to evaluate and summarize the efficacy and safety of extracellular vesicles (EVs) and conditioned media (CM) as emerging therapeutic approaches in regenerative medicine for skin rejuvenation and lightening. METHODS: A systematic search was conducted up to September 19, 2024, using the PubMed, Scopus, and Web of Science databases. Keywords included "conditioned media,"...

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: Studies have reported promising results of mesenchymal stem cell therapies for skin aging. However, in the use of mesenchymal stem cells, some drawbacks including rarely possible tumorigenicity and low engraftment rates have limited their widespread clinical use. Adipose tissue stem cell-derived exosomes (ASCEs) are emerging as effective cell-free therapeutic agents.

Randomized Controlled Trial, Journal Article

Abstract summary (English) Mesenchymal stem cell (MSC)-derived exosomes are emerging as cell-free bioregenerative platforms in aesthetic dermatology. Umbilical cord (UC-MSC) and adipose-derived (AD-MSC) exosomes are among the most studied sources, yet existing data derive from heterogeneous models that preclude direct comparison. No standardized head-to-head evaluation in a human skin aging model has been conducted.

Journal Article, Comparative Study

Abstract summary (English) Exosomes have emerged as promising agents in regenerative medicine because of their ability to mediate intercellular communication, modulate inflammation, and promote tissue repair. However, their clinical application remains limited by issues of stability, bioavailability, and therapeutic consistency. Hybrosomes, engineered hybrid vesicles that combine exosomal membranes with liposomal structures, have been...

Journal Article, Review, Comparative Study

Abstract summary (English) BACKGROUND: Numerous retinoid-based skincare products are available over-the-counter for photodamaged and photoaged skin, but are associated with objective (e.g., erythema, dryness, flaking, edema) and subjective (e.g., itching, tingling, stinging, burning) tolerability issues. A novel retinal formulation was developed using an engineered biomimetic vegan exosome as a delivery system. The formulation also contains...

Journal Article, Clinical Trial

Abstract summary (English) BACKGROUND: Exosomes, an emerging treatment of interest to aesthetic dermatology, have therapeutic applications in skin rejuvenation, alopecia, atopic dermatitis, acne scarring, and wound healing. Platelet-rich plasma has been widely utilized for the same indications, among others. Currently, there are no trials comparing the two regenerative modalities in aesthetic dermatology.

Comparative Study, Controlled Clinical Trial, Equivalence Trial, Journal Article

Abstract summary (English) Background and Objectives: This three-year clinical trial aimed to demonstrate that only the signaling vesicles produced by ADSCa, containing mRNA, microRNA, growth factors (GFs), and bioactive peptides, provide an advantage over classical therapy with adipose disaggregate to make the tissue regeneration technique safer due to the absence of interfering materials and cells, while being extremely minimally...

Clinical Trial, Journal Article