GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Skin Quality · Photodamaged skin / texture

Chemical peel evidence for Photodamaged skin / texture

B 51.6 / 100 Supported 26 RCT/meta · 33 clinical/observational · 17 case · 262 total
Good evidence · positive conclusion

There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Includes meta-analysis/SR Median year 2009 Last 5 years 16% Positive results 34% Negative results 9 Korea/Asia 15

Known in Korea as

라라필밀크필블랙필플라필각질제거 피지제거 라라필

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 What's New With Under Eye Treatment: A Multispecialty Systematic Review of Recent Under Eye Treatments. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2025 · PMID 41615388

Abstract summary (English) BACKGROUND: Infraorbital hollowing and hyperpigmentation are common cosmetic concerns resulting from structural volume loss, pigmentary changes, vascular prominence, and skin laxity. OBJECTIVE: To systematically review current and emerging treatments for infraorbital concerns with an emphasis on patient selection and anatomy-driven approaches. MATERIALS AND METHODS: A systematic PubMed search was conducted in March...

Journal Article, Systematic Review

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tier1 Enhancing Facial Rejuvenation Outcomes With a Novel Retinaldehyde-Based Cream: A Comparative Randomized Intra-Individual Study. Journal of cosmetic dermatology · 2025 · PMID 41312593

Abstract summary (English) BACKGROUND: Minimally-to-moderately invasive facial rejuvenation procedures, such as chemical peels, hyaluronic acid (HA) injections and fractional lasers, yield visible improvements in skin texture, tone and wrinkles; their long-term benefits can be optimized through a targeted anti-aging skincare regimen. AIMS: This controlled study aimed to evaluate the tolerability and efficacy of a cream containing three...

Journal Article, Randomized Controlled Trial, Comparative Study

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tier1 Efficacy of combined 1927 nm thulium fiber laser and supramolecular salicylic acid in photoaging treatment. Lasers in medical science · 2025 · PMID 40960645

Abstract summary (English) PURPOSE: 1927 nm fractional thulium fiber laser (TFL) has been shown to be effective in improving skin appearance by reducing pigmentation and loss of elasticity caused by photoaging. Supramolecular salicylic acid (SSA) has been utilized for chemical peeling with rejuvenation effect. This study aims to evaluate the effectiveness and safety of combined TFL and SSA treatment for photoaging.

Journal Article, Randomized Controlled Trial

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tier1 The Impact of an AGE-Inhibiting Moisturizer on Procedure Effectiveness. Journal of drugs in dermatology : JDD · 2025 · PMID 40911740

Abstract summary (English) The accumulation of endogenous advanced glycation end products (AGEs) has been shown to degrade the integrity of the extracellular matrix in the dermis, resulting in signs of aging. Resurfacing procedures are a first-line treatment option. Post-procedure skin care is integral in achieving optimal results with minimal downtime.

Journal Article, Randomized Controlled Trial

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tier1 Synergistic Enhancement of Compromised Skin Radiance: A Clinical Investigation of Prinsepia utilis Royle Polysaccharides and Nonapeptide Co-Application. Journal of cosmetic dermatology · 2025 · PMID 40367144

Abstract summary (English) BACKGROUND: Skin radiance represents both healthy and esthetic aspects of human skin, usually influenced by a compromised barrier and the aging process. The reduction of the stratum corneum by chemical peels is a prevalent procedure employed to enhance facial radiance, but peeling is not suitable for compromised skin. OBJECTIVES: Prinsepia utilis Royle polysaccharides (PURP) is a natural extract with repairing...

Journal Article, Randomized Controlled Trial

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tier1 High-frequency ultrasound in anti-aging skin therapy monitoring. Scientific reports · 2023 · PMID 37853086

Abstract summary (English) Over the last few decades, high-frequency ultrasound has found multiple applications in various diagnostic fields. The fast development of this imaging technique opens up new diagnostic paths in dermatology, allergology, cosmetology, and aesthetic medicine. In this paper, being the first in this area, we discuss the usability of HFUS in anti-aging skin therapy assessment.

Randomized Controlled Trial, Journal Article, Research Support, Non-U.S. Gov't

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tier1 Efficacy and safety of a new peeling formulated with a pool of PHAs for the treatment of all skin types, even sensitive. Journal of cosmetic dermatology · 2022 · PMID 35796684

Abstract summary (English) BACKGROUND: Actually, the use of chemical peels in cosmetics and dermatology continues to grow due to their versatility, clinical endpoint-directed predictability, and favorable risk profile in comparison to lasers. The chemical peel is a generally safe method for treatment of some skin disorders and to refresh and rejuvenate the skin. The major challenge of chemical peels is the tolerability, that is because of...

Journal Article, Randomized Controlled Trial

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tier1 Cosmetic use of three topical moisturizers following glycolic acid facial peels. Journal of cosmetic dermatology · 2019 · PMID 31322804

Abstract summary (English) BACKGROUND: Facial chemical exfoliation (peeling) involves using a chemical agent to insult the skin and damage the cutaneous barrier, to reduce the signs of aging. The use of a moisturizer is advised postprocedure to promote repair of the epidermis. Biomimic moisturizer formulations may be effective treatment options for repair following facial peeling.

Journal Article, Randomized Controlled Trial

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tier1 Antiaging efficacy of a retinaldehyde-based cream compared with glycolic acid peel sessions: A randomized controlled study. Journal of cosmetic dermatology · 2018 · PMID 30027612

Abstract summary (English) BACKGROUND: Glycolic acid (GA) chemical peels are a popular treatment for photoaged skin rejuvenation, but retinaldehyde (RAL)-based cosmetic creams have also demonstrated efficacy in improving photoaging, and are potentially better tolerated than chemical peels. AIMS: To compare the efficacy and safety of an antiaging cream containing 0.1% RAL associated with Glycylglycine Oleamide (GGO, Relastide® ) and...

Comparative Study, Journal Article, Randomized Controlled Trial

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tier1 Combining microneedling with other minimally invasive procedures for facial rejuvenation: a split-face comparative study. International journal of dermatology · 2018 · PMID 30105816

Abstract summary (English) BACKGROUND: The introduction of minimally invasive procedures has increased acceptance due to their efficacy, safety, and relatively long-lasting and natural results. At least two different and unrelated modalities are employed to consider a combination treatment. OBJECTIVES: This study aims to evaluate and compare the use and effectiveness of combined microneedling with platelet-rich plasma (PRP) or trichloroacetic...

Comparative Study, Journal Article, Randomized Controlled Trial

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Suggested interpretation

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