GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Volume / Contour · Jawline contour definition

CaHA filler evidence for Jawline contour definition

B 56.6 / 100 Supported 6 RCT/meta · 3 clinical/observational · 2 case · 28 total
Good evidence · positive conclusion

There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Includes meta-analysis/SR Median year 2023 Last 5 years 64% Positive results 39% Korea/Asia 1

Known in Korea as

레디어스

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Microfocused Ultrasound With Visualization (MFU-V) and Hyperdilute Calcium Hydroxylapatite (CaHA-CMC) of the Lower Face and Submentum to Treat Skin Laxity: A Pilot Study Demonstrating Superiority of MFU-V First Followed by Hyperdilute CaHA-CMC. Aesthetic surgery journal · 2025 · PMID 39511699

Abstract summary (English) BACKGROUND: Microfocused ultrasound with visualization (MFU-V) and hyperdilute calcium hydroxylapatite-carboxymethylcellulose (CaHA-CMC) dermal injections are effective for improving skin laxity in the lower face and submentum by stimulating neocollagenesis and neoelastogenesis. OBJECTIVES: Combining these treatments in an optimal order may inform best practice in aesthetic dermatology. Despite their frequent...

Journal Article, Randomized Controlled Trial

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tier1 Long-term duration and safety of Radiesse (+) for the treatment of jawline. Journal of cosmetic dermatology · 2024 · PMID 38934231

Abstract summary (English) BACKGROUND: Calcium hydroxyapatite (CaHA)-carboxymethylcellulose (CMC)+ has unique properties that make it optimal for lifting, contouring, and defining the jawline. This long-term follow-up of a randomized, multicenter, rater-blinded trial reports efficacy and safety of CaHA-CMC(+) through 48 and up to 60 weeks post-treatment. METHODS: Eligible patients were randomized (2:1) to the treatment or the control/delayed...

Journal Article, Randomized Controlled Trial, Multicenter Study

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tier1 A systematic review of Radiesse/calcium hydroxylapatite and carboxymethylcellulose: evidence and recommendations for treatment of the face. International journal of dermatology · 2023 · PMID 37897174

Abstract summary (English) Radiesse® is a filler composed of calcium hydroxylapatite microspheres suspended in a carboxymethylcellulose gel (CaHA/CMC). It has robust rheological properties that have been associated with its versatility. CaHA/CMC is employed for both on-label indications of filling wrinkles or lines, volumizing, and contouring of areas as well as off-label indications aiming at biostimulation and skin tightening.

Systematic Review, Journal Article

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tier1 A Randomized, Evaluator-Blind, Split-Face Study Evaluating the Safety and Efficacy of Calcium Hydroxylapatite for Jawline Augmentation. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2022 · PMID 33731569

Abstract summary (English) INTRODUCTION: Jawline augmentation with calcium hydroxylapatite has not yet been evaluated in a prospective study with a split-face design. This study aims to perform the first randomized controlled, split-face study on the efficacy and safety of calcium hydroxylapatite for jawline augmentation using the needle and cannula technique. OBJECTIVE: To perform the first randomized controlled, split-face study on the...

Journal Article, Randomized Controlled Trial

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tier1 Effectiveness and Safety of Calcium Hydroxylapatite With Lidocaine for Improving Jawline Contour. Journal of drugs in dermatology : JDD · 2021 · PMID 34784131

Abstract summary (English) BACKGROUND: One of the early signs of aging is loss of jawline contour. Not all cases require surgical intervention and soft-tissue augmentation with injectable fillers may restore the profile and youthful appearance of the jawline. OBJECTIVE: To demonstrate the effectiveness and safety of calcium hydroxylapatite with lidocaine [CaHA (+); Radiesse® (+)] to improve the contour of jawline after deep (subdermal...

Journal Article, Randomized Controlled Trial

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tier1 Combination of Calcium Hydroxylapatite Diluted With Normal Saline and Microfocused Ultrasound With Visualization for Skin Tightening. Journal of drugs in dermatology : JDD · 2020 · PMID 32272518

Abstract summary (English) Background/Objectives: Treatment options for the correction of age-related changes in skin include the use of energy-based devices and dermal fillers. In this study, we evaluate the clinical efficacy and tolerability of microfocused ultrasound with visualization (MFU-V) and injectable calcium hydroxylapatite (CaHA) filler diluted with normal saline, for the correction of age-related changes and to assess patients'...

Journal Article, Randomized Controlled Trial

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tier2 A Novel Six-Point Supraperiosteum Injection with Calcium Hydroxyapatite for Jawline Refining and Facial Anti-aging in Asian Patients. Aesthetic plastic surgery · 2025 · PMID 40610809

Abstract summary (English) BACKGROUND: Supraperiosteal injection by calcium hydroxyapatite (CaHA) fillers is an efficient treatment for facial rejuvenation to achieve bony recontouring, facial augmentation and lifting. However, a safe and efficient injection technique for Asians was not described, and an assessment scale to quantify "facial anti-aging" does not exist. METHODS: We enrolled 16 Asian women (n = 32) to receive a single session of...

Clinical Study, Journal Article

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tier2 Long lasting facial rejuvenation by repeated placement of calcium hydroxylapatite in elderly women. Dermatologic therapy · 2020 · PMID 32794331

Abstract summary (English) Calcium hydroxylapatite (CaHA) is a biostimulatory filler with long lasting efficacy after a single injection. Data con the effect of repeated injections, however, are sparse. This is a single-center observational study.

Journal Article, Observational Study

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tier2 Restoring jawline contour with calcium hydroxylapatite: A prospective, observational study. Journal of cosmetic dermatology · 2017 · PMID 28675618

Abstract summary (English) BACKGROUND: Jawline reshaping by replacing volume has become an indispensable component of modern facial rejuvenation. AIM: To evaluate calcium hydroxylapatite (CaHA) for the treatment of an aging jawline in a routine setting. METHODS: Five investigators enrolled 35 subjects requesting jawline rejuvenation with CaHA.

Journal Article, Observational Study

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tier0_review Nonsurgical Chin and Prejowl Modification. Facial plastic surgery : FPS · 2025 · PMID 40389235

Abstract summary (English) The chin and prejowl areas play a critical role in the perception of facial harmony. This paper explores nonsurgical approaches for chin and prejowl rejuvenation, emphasizing anatomy, aesthetic concerns, and the plethora of available treatment modalities.Bony landmarks such as the pogonion, menton, and mental protuberance define the chin, while muscles like the mentalis, depressor anguli oris (DAO), and depressor...

Journal Article, Review

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