Pigment · Freckles / ephelides
Picosecond laser pigment evidence for Freckles / ephelides
There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.
Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.
Median year 2022 Last 5 years 71% Positive results 100% Korea/Asia 5
Known in Korea as
Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.
Key papers
tier1 730-nm, 532-nm and 694-nm laser in the treatment of freckles and solar lentigines (A randomized clinical trial).
Abstract summary (English) OBJECTIVE: This study aims to assess the effectiveness and safety of the 730-nm picosecond laser, the 532-nm picosecond laser, and the Q-switched 694-nm nanosecond laser in treating freckles and solar lentigines. METHODS: The randomized clinical trial included 42 participants who met the specific eligibility criteria for freckles and solar lentigines. On each participant's face, three distinct skin areas affected by...
Journal Article, Randomized Controlled Trial
View on PubMedtier1 Comparison of the efficacy and safety of a 730 nm picosecond titanium sapphire laser and a 755 nm picosecond alexandrite laser for the treatment of freckles in Asian patients: A two-center randomized, split-face, controlled trial.
Abstract summary (English) OBJECTIVE: The 730 nm picosecond titanium sapphire laser is a novel laser that shows promising results in treating freckles. This study aimed to further investigate the efficacy and safety of the 730 nm picosecond titanium sapphire laser for treating freckles in Asian patients compared with those of the 755 nm picosecond alexandrite laser. METHODS: Each face of 86 participants was split into two parts and randomly...
Randomized Controlled Trial, Case Reports, Journal Article
View on PubMedtier1 Split-face comparison of the efficacy of picosecond 532 nm Nd:YAG laser and Q-switched 755 nm Alexandrite laser for treatment of freckles.
Abstract summary (English) To date, there has been little study of comparison between picosecond 532 nm laser and 755 nm Q-switched Alexandrite lasers in the treatment of freckles. To evaluate the efficacy and safety of picosecond 532 nm laser (PS 532) and 755 nm Q-switched Alexandrite laser (QSAL) for treatment of freckles in a split-face manner. Eighteen patients with freckles were enrolled in the study.
Journal Article, Randomized Controlled Trial
View on PubMedtier2 Evaluation of the safety and efficacy of the dual wavelength picosecond laser for the treatment of benign pigmented lesions in Asians.
Abstract summary (English) BACKGROUND AND OBJECTIVES: Cutaneous pigmentary disorders are both more common and more difficult to treat in patients with skin color given the higher melanin content in the epidermis. Although Q-switched lasers are widely considered to be the standard treatment for both epidermal and dermal pigmentary conditions, a very high risk of post-inflammatory hyperpigmentation (PIH) of up to 25% is seen in patients with...
Clinical Study, Journal Article
View on PubMedtier3 Treatment of facial pigmented disorders with a 785-nm picosecond Ti:sapphire laser in Asians: A report of three cases.
Abstract summary (English) Since the advent of the theory of selective photothermolysis, the importance of targeting the chromophore and minimizing the surrounding damage has been extensively discussed. Picosecond-domain laser (ps-laser) treatment with a wide range of wavelengths is an emerging option for various pigmented lesions; however, no definitive treatment choice has been confirmed. The authors aimed to investigate the efficacy and...
Case Reports, Journal Article
View on PubMedtier3 Successful Treatment of Pigmentary Disorders in Asians With a Novel 730-nm Picosecond Laser.
Abstract summary (English) BACKGROUND AND OBJECTIVE: Until recently, quality-switched nanosecond lasers have been the workhorse lasers in treating pigmented lesions. However, the recently commercialized picosecond lasers have provided physicians with a novel method to manage pigmented lesions. Most recently, the first picosecond laser with a 730-nm wavelength was developed to specifically target melanin and melanocytes.
Case Reports, Journal Article
View on PubMedtier_other Successful Treatment of Freckles Using a 730-nm Picosecond Laser: A Prospective Study.
Abstract summary (English) OBJECTIVE: Freckles are common hyperpigmented diseases that commonly occur in Caucasians and Asians. Freckles often cause cosmetic and even psychosocial concerns. Various lasers with different wavelengths have been used to treat pigmented spots.
Journal Article
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