Photodynamic therapy evidence for BCC superficial

Abstract summary (English) BACKGROUND: Basal cell carcinoma (BCC) is the most prevalent non-melanoma skin cancer, with surgical excision as the gold standard-though it carries risks of cosmetic scarring and functional impairment. Photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) emerges as a non-invasive alternative, yet evidence on its relative efficacy across superficial (sBCC) and nodular (nBCC)...

Journal Article, Systematic Review

Abstract summary (English) In vivo reflectance confocal microscopy (RCM) enables monitoring of non-melanocytic skin cancers (NMSC) treated with non-invasive or minimally invasive therapies. This systematic review analyzed studies on NMSC treated with these therapies and monitored by RCM. A total of 56 articles were included, with 40 focusing on squamous conditions, such as actinic keratosis and squamous cell carcinoma, 15 on basal cell...

Journal Article, Systematic Review

Abstract summary (English) SIGNIFICANCE: Noninvasive imaging to accurately measure subtle changes in tumor size is underutilized when assessing therapeutic responses in the skin. During photodynamic therapy (PDT) for basal cell carcinoma (BCC), a better definition of the tumor size threshold for PDT responsiveness is needed. AIM: We aim to quantitatively demonstrate the first clinical evidence of tumor shrinkage after multiple rounds of PDT...

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Surgical procedures remain the gold standard for treating basal cell carcinoma (BCC), although commonly associated with cosmetic defects. The demand for noninvasive alternatives remains high. OBJECTIVE: To determine efficacy and safety of red light photodynamic therapy (PDT) with 10% 5-aminolevulinic acid (ALA) gel vs vehicle for treatment of superficial BCC.

Journal Article, Randomized Controlled Trial, Multicenter Study, Clinical Trial, Phase III

Abstract summary (English) BACKGROUND: Photodynamic therapy (PDT) is a recognized treatment for superficial basal cell carcinoma (sBCC). Conventional PDT (C-PDT) has a relatively high clearance rate but is time-consuming and painful. Simulated daylight PDT (SDL-PDT) has the potential advantage of causing less pain, but its effectiveness has not been investigated thoroughly.

Equivalence Trial, Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Combining Vitamin D (VD) with photodynamic therapy (PDT) increases the clearance of actinic keratosis, but whether this might also be true for basal cell carcinoma (BCC) was unknown. PATIENT AND METHODS: In an intra-patient, randomized clinical trial, 35 patients with multiple BCC received 3 sessions of PDT using 20 % ALA (4 hr incubation) and 417 nm light. PDT was preceded by randomized pretreatments...

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Photodynamic therapy (PDT) can target cancers, while causing little damage to surrounding healthy tissues. OBJECTIVE: To systematically evaluate the efficacy, safety, and clinical applications of PDT across cancer types. METHODS: PubMed, EMBASE, Cochrane Library, and Web of Science were searched to April 7, 2024 for systematic reviews and meta-analyses of PDT in patients with cancer.

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: Topical Photodynamic Therapy (PDT) is a well-studied and effective treatment for basal cell carcinoma (BCC) and pre-malignant lesions. Developing a cheaper approach to this treatment involves local production of aminolevulinic acid (ALA) and methyl aminolevulinate (MAL). Furthermore, a prospective study to verify its clinical effectiveness and advantages was required.

Journal Article, Randomized Controlled Trial, Comparative Study

Abstract summary (English) BACKGROUND: 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is used off-label in the US to treat basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and Bowen disease (BD). We performed a systematic review to assess the efficacy and safety of published ALA-PDT protocols for these conditions. METHODS: A PubMed search was conducted through August 8, 2024, to identify studies evaluating 10 % or 20 % ALA-PDT...

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: Non-surgical treatments are cost-effective options for low-risk basal cell carcinomas (BCCs) i.e. superficial or small nodular BCCs located outside the high-risk locations. Hexyl aminolevulinate (HAL) and 5-aminolevulinic acid nanoemulsion (BF-200 ALA) with enhanced penetration depth enables the use of lower concentrations compared to methylaminolevulinate (MAL) in photodynamic therapy (PDT).

Journal Article, Randomized Controlled Trial