GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Lifting / Laxity · Striae distensae

Nonablative fractional resurfacing evidence for Striae distensae

B 56.3 / 100 Supported 5 RCT/meta · 2 clinical/observational · 1 case · 20 total
Good evidence · positive conclusion

There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Includes meta-analysis/SR Median year 2018 Last 5 years 33% Positive results 71% Korea/Asia 4

Known in Korea as

라셈드MOXI헤일로 레이저

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Advances in the Treatment of Striae Distensae. Journal of cosmetic dermatology · 2026 · PMID 41560402

Abstract summary (English) BACKGROUND: Striae distensae (SD) is a common cutaneous condition with an estimated incidence of 56%, associated with rapid skin expansion, hormonal changes, and genetic factors. While traditional treatments (e.g., topical tretinoin, various lasers) exhibit limitations, non-ablative fractional laser (NAFL), injectable fillers, alpha hydroxy acids (AHAs), and combination therapies have emerged as promising...

Journal Article, Systematic Review

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tier1 Clinical Efficacy Comparisons Between Poly-L-Lactic Acid Injections and Non-Ablative 1565-nm Fractional Laser for Treatment of Striae Distensae-A Randomized Trial. Journal of cosmetic dermatology · 2025 · PMID 40662320

Abstract summary (English) BACKGROUND: Despite numerous treatment modalities for striae distensae (SD), a definitive gold standard therapy remains unidentified. AIMS: This study aims to evaluate and compare the efficacy of injectable poly-L-lactic acid (PLLA) with a 1565-nm non-ablative fractional laser (NAFL) in treating SD located in the abdominal area. METHODS: 40 women with SD were randomly assigned to one of four treatment groups: (1)...

Journal Article, Randomized Controlled Trial, Comparative Study

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tier1 Improving the outcome of treating striae gravidarum by combined therapies using topical β-glucan and 1565-nm non-ablative fractional laser: A prospective randomized vehicle-controlled parallel group study. The Journal of dermatology · 2022 · PMID 35570397

Abstract summary (English) Striae gravidarum (SG) is a kind of dermal scar associated with psychosocial and therapeutic challenge. Topical reagents and non-invasive laser are more preferred than invasive procedures for less pain and shorter downtime. However, there are few studies on comparing and combining these two modalities.

Journal Article, Randomized Controlled Trial

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tier1 Comparative study of treatment for striae alba stage striae gravidarum: 1565-nm non-ablative fractional laser versus fractional microneedle radiofrequency. Lasers in medical science · 2021 · PMID 33411130

Abstract summary (English) Striae gravidarum is a common dermatologic condition for females caused by multiple factors during pregnancy. It remains a therapeutic challenge especially in the striae alba (SA) stage, generating psychological and emotional distress to those affected. This study aims to compare the efficacy and safety of 1565-nm non-ablative fractional laser (NAFL) and fractional microneedle radiofrequency (MRF) for treatment of...

Journal Article, Randomized Controlled Trial

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tier1 Efficacy of Microneedling Versus Fractional Non-ablative Laser to Treat Striae Alba: A Randomized Study. American journal of clinical dermatology · 2019 · PMID 30618025

Abstract summary (English) BACKGROUND: Striae distensae (SD), an unsightly cutaneous condition characterized by epidermal atrophy, can affect the quality of life of women. OBJECTIVES: The aim of our study was to compare the efficacy of a neodymium:yttrium-aluminum-perovskite 1340 nm non-ablative fractional laser (NAFL) and the microneedling (MN) technique to treat striae alba (SA). MATERIALS AND METHODS: NAFL and MN were used to treat striae...

Comparative Study, Journal Article, Randomized Controlled Trial

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tier2 A Comparison Study of the Nonablative Fractional 1565-nm Er: glass and the Picosecond Fractional 1064/532-nm Nd: YAG Lasers in the Treatment of Striae Alba: A Split Body Double-Blinded Trial. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2018 · PMID 29746426

Abstract summary (English) BACKGROUND: Few effective treatments exist for striae alba, which are the mature stage of stretch marks. OBJECTIVE: To evaluate the efficacy of the nonablative fractional 1,565-nm Erbium-glass (Er:glass) and the picosecond fractional 1,064/532-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) lasers in the treatment of striae alba. MATERIALS AND METHODS: Twenty subjects with striae alba on the bilateral abdomen were...

Clinical Trial, Comparative Study, Journal Article

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tier2 A novel 1565 nm non-ablative fractional device for stretch marks: A preliminary report. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology · 2015 · PMID 25633176

Abstract summary (English) BACKGROUND: Striae Distensae (SD) is a very common dermatologic condition. We evaluated the effectiveness and safety of a novel non-ablative fractional 1565 nm laser (ResurFX) on the appearance of SD. MATERIALS AND METHODS: Twelve Caucasian subjects with various stages of SD received three non-ablative laser treatments.

Clinical Trial, Journal Article

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tier0_review Advancements in treating stretch marks across all skin types: a comprehensive review of therapeutic modalities. International journal of women's dermatology · 2026 · PMID 41537058

Abstract summary (English) BACKGROUND: Striae distensae (SD) (stretch marks) are common dermal scars resulting from rapid skin stretching during puberty, pregnancy, or weight changes and disproportionately affect women. Management remains challenging, particularly in individuals with darker skin tones, due to variable efficacy and the risk of postinflammatory hyperpigmentation with certain therapies. OBJECTIVE: To review current and emerging...

Journal Article, Review

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tier0_review Striae gravidarum: Risk factors, prevention, and management. International journal of women's dermatology · 2016 · PMID 28560300

Abstract summary (English) BACKGROUND: Striae gravidarum (SG) are atrophic linear scars that represent one of the most common connective tissue changes during pregnancy. SG can cause emotional and psychological distress for many women. Research on risk factors, prevention, and management of SG has been often inconclusive.

Journal Article, Review

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tier3 Striae after topical corticosteroid: Treatment with nonablative fractional laser 1540nm. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology · 2015 · PMID 25549814

Abstract summary (English) Striae distensae are atrophic dermal scars associated with psychosocial stress. Several treatments have been used but there is no gold standard until now. Fractional photothermolysis has been described as a successful and safe method to treat scars.

Case Reports, Journal Article

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