GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Hyperhidrosis · Axillary hyperhidrosis

Microneedling RF evidence for Axillary hyperhidrosis

C 44.0 / 100 Supported 2 RCT/meta · 2 clinical/observational · 2 case · 11 total
Early-stage evidence

This is an early evidence stage based mainly on observational studies and case reports. Use it as supplementary reference, and follow your doctor's judgment for treatment decisions.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Median year 2019 Last 5 years 27% Positive results 73% Negative results 1 Korea/Asia 2

Known in Korea as

실펌포텐자버츄RF아그네스프로파운드

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Long-term efficacy of fractional microneedle radiofrequency versus botulinum toxin-A in primary axillary hyperhidrosis: a randomized controlled trial. Lasers in medical science · 2024 · PMID 38981914

Abstract summary (English) Primary axillary hyperhidrosis is an idiopathic disorder that creates severe psycho-social burden due to excessive uncontrolled sweating. Various therapeutic agents have been described, but each has its own limitations. The use of fractional microneedling radiofrequency has emerged lately with promising results.

Journal Article, Randomized Controlled Trial, Comparative Study

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tier1 A comparative study between intradermal botulinum toxin A and fractional microneedle radiofrequency (FMR) for the treatment of primary axillary hyperhidrosis. Lasers in medical science · 2020 · PMID 31939036

Abstract summary (English) Microneedle radiofrequency (FMR) for the treatment of primary axillary hyperhidrosis radiofrequency (RF) technology is a new modality that applied deep heat energy directly affecting the epidermis and dermis. Limiting data about FMR for axillary hyperhidrosis is concerning. To compare clinical efficacy between fractional microneedle radiofrequency and intradermal botulinum toxin type A injection.

Comparative Study, Journal Article, Randomized Controlled Trial

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tier2 Split-axilla comparison study of 0.5-MHz, invasive, bipolar radiofrequency treatment using insulated microneedle electrodes for primary axillary hyperhidrosis. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2018 · PMID 29790612

Abstract summary (English) BACKGROUND: Energy-delivering devices can be used to induce thermal coagulation of the eccrine sweat glands for treating primary axillary hyperhidrosis (PAH). OBJECTIVE: The objective of this study was to compare the efficacy and safety of invasive, bipolar radiofrequency (RF) treatment for PAH. METHODS: A split-axilla study was performed to compare the clinical outcomes of 0.5 MHz, invasive, bipolar RF treatment...

Comparative Study, Journal Article

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tier2 Fractionated microneedle radiofrequency for treatment of primary axillary hyperhidrosis: A sham control study. The Australasian journal of dermatology · 2014 · PMID 25496000

Abstract summary (English) BACKGROUND/ OBJECTIVE: Primary axillary hyperhidrosis (PAH) creates social stress in patients. Although there are several options for treating PAH, only surgical modalities have conferred a permanent solution. This study evaluated the clinical effectiveness of fractionated microneedle radiofrequency (FMR) treatment for PAH.

Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't

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tier0_review Axillary Osmidrosis: Past, Present, and Future. Annals of plastic surgery · 2020 · PMID 31850965

Abstract summary (English) Axillary osmidrosis is characterized by offensive odor resulting from bacterial decomposition of apocrine secretions in the axillae, and individuals with axillary osmidrosis suffer detrimental effects to their psychosocial functioning. We searched the literature in January 2019 for all English-language publications discussing axillary osmidrosis to identify previous reports, present trends, and emerging treatments....

Journal Article, Review

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tier0_review The etiology, diagnosis, and management of hyperhidrosis: A comprehensive review: Therapeutic options. Journal of the American Academy of Dermatology · 2019 · PMID 30710603

Abstract summary (English) Hyperhidrosis (HH) is a chronic disorder of excess sweat production that may have a significant adverse effect on quality of life. A variety of treatment modalities currently exist to manage HH. Initial treatment includes lifestyle and behavioral recommendations.

Journal Article, Review

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tier_other Experience of negative pressure fractional microneedle radiofrequency therapy for axillary osmidrosis: a case study. Archives of dermatological research · 2024 · PMID 39636411

Abstract summary (English) BACKGROUND: Negative pressure fractional microneedle radiofrequency (NPFMR) therapy has emerged as a potential minimally invasive treatment for axillary osmidrosis (AO), a condition characterized by persistent strong body odor from the armpit area. METHODS: This case study aims to assess the efficacy and safety of NPFMR for AO treatment. From January to September 2024, 30 patients with AO were recruited, with a...

Journal Article

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tier_other The efficacy and safety of a fractional microneedle radiofrequency device for the treatment of axillary hyperhidrosis: clinical prospective pilot study. Lasers in medical science · 2021 · PMID 34453655

Abstract summary (English) We aimed to evaluate the efficacy and safety of a fractional microneedle radiofrequency device (FMRD) for the treatment of primary axillary hyperhidrosis (PAH). The FMRD adopted insulated microneedles, which could be located at a depth of up to 4.5 mm and deliver a radiofrequency current in a fractional manner. Also, the device could automatically regulate the amount of the delivered energy.

Journal Article

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tier_other Treatment of Primary Axillary Hyperhidrosis by Fractional Microneedle Radiofrequency: Is it Still Effective after Long-term Follow-up? Indian journal of dermatology · 2016 · PMID 27057039

Abstract summary (English) BACKGROUND: Primary axillary hyperhidrosis (PAH) is a chronic idiopathic disorder causing major stress in patients. Among the common therapies for PAH, only surgical interventions have proven feasible as a permanent solution. OBJECTIVE AND AIM: The aim of this study was to evaluate the efficacy and safety of fractional microneedle radiofrequency (FMR) as an alternative permanent treatment for PAH with long-term...

Journal Article

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tier_other Quality of life in patients with primary axillary hyperhidrosis before and after treatment with fractionated microneedle radiofrequency. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015 · PMID 26622250

Abstract summary (English) BACKGROUND: Primary axillary hyperhidrosis (PAH) is a common condition with a great impact on the patient's quality of life (QOL). It is associated with serious social, emotional, and occupational distress. The aim of this study was to investigate the QOL in patients with PAH before and after treatment with fractionated microneedle radiofrequency (FMR).

Journal Article

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Suggested interpretation

Limited evidence

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