LED phototherapy evidence for Chronic wound / diabetic ulcer

Abstract summary (English) OBJECTIVE: This study aimed to comprehensively compare the efficacy of 12 interventions for diabetic foot ulcer (DFU) using a network meta-analysis (NMA). METHODS: The NMA was conducted by PRISMA guidelines, and the protocol was registered in PROSPERO (CRD42023461811). PubMed, Web of Science, Cochrane Library, and Embase databases were systematically searched from inception to September 2023.

Comparative Study, Journal Article, Network Meta-Analysis, Systematic Review

Abstract summary (English) Objective: To evaluate the effectiveness of non-pharmacological interventions in treating chronic wound pain in patients. Methods: This study was a systematic review and Bayesian network meta-analysis. Randomized controlled trials on the effectiveness of non-pharmacological interventions in treating chronic wound pain in patients, published from the establishment of the database until June 30, 2024,...

English Abstract, Journal Article, Network Meta-Analysis, Systematic Review

Abstract summary (English) This study aimed to systematically verify the available systematic reviews and meta-analyses of Low-level laser therapy (LLLT) in diabetic foot ulcer (DFUs) to identify the effects and optimal parameters of LLLT in the management of DFUs. This umbrella review was written according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) report items and registered in the International...

Journal Article, Systematic Review

Abstract summary (English) Assessing the responses to the application of photobiomodulation using red and infrared spectrum light-emitting diodes (LED) on diabetic foot ulcers. Diabetic volunteers, of both genders, aged between 30 and 65 years, with grade I or II ulcers, were randomized into the groups: red LED, infrared LED, LED associated, and control. Home-based interventions took place on a daily basis for 12 weeks.

Journal Article, Randomized Controlled Trial

Abstract summary (English) OBJECTIVE: To evaluate the quality of life (QoL) of patients with a diabetic foot ulcer undergoing treatment with low-level laser therapy (LLLT) at 904 nm and its association with self-care. METHODS: In this randomized, exploratory study, participants were divided into the following four groups: control group (CG) with LLLT placebo, LLLT group 1 (LG1) at 10 J/cm2, LLLT group 2 (LG2) at 8 J/cm2, and LLLT group 3...

Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

Abstract summary (English) Background: Impaired angiogenesis is a significant factor contributing to delayed healing in diabetic foot ulcers (DFUs) due to inadequate oxygenation. Objective: This study aimed to investigate the impact of photobiomodulation (PBM) using a Ga-As laser on the release of serum hypoxia-inducible factor 1-α (HIF-1α), vascular endothelial growth factor (VEGF), vascular endothelial growth...

Journal Article, Randomized Controlled Trial

Abstract summary (English) Tissue injuries that affect the skin and/or adjacent tissues and are usually over a bony prominence are called pressure injuries. The prevalence of these dysfunctions remains high, and despite technological advances, there is no consensus on the most appropriate treatment. The objective of this review was to evaluate the efficacy of photobiomodulation (PBM), ultrasound, and high-frequency electrophysical agents in...

Systematic Review, Journal Article

Abstract summary (English) Infected diabetic foot ulcers (iDFUs) cause great concern, as they generally heal poorly and are precursive of diabetic-related foot amputation and even death. Scientists have tested various techniques in attempts to ascertain the best treatment for iDFUs; however, the results have remained inconclusive. Stem cell therapy (SCT) appears to improve iDFU through its antimicrobial impacts, yet cogent information...

Systematic Review, Journal Article

Abstract summary (English) The primary goal of this systematic review article was to provide an outline of the use of diabetic autologous adipose-derived mesenchymal stem cells (DAAD-MSCs) in the treatment of wounds and ulcers in animal models and patients with diabetes mellitus (DM). The secondary goal was to present the outcomes of pretreatment of diabetic adipose-derived mesenchymal stem cells (DAD-MSCs) with probable different agents in...

Journal Article, Systematic Review

Abstract summary (English) PURPOSE: To evaluate the safety and efficacy of an at-home photobiomodulation (PBM) device for the treatment of diabetic foot ulcers (DFUs) in a frail population with severe comorbidities. METHODS: Prospective, randomized, double-blind, sham-controlled pilot study. Patients (age = 63 ± 11 years, male:female 13:7) with insulin-dependent diabetes type 2, neuropathy, peripheral artery disease, significant...

Journal Article, Randomized Controlled Trial