GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Vascular · Rosacea erythematotelangiectatic

IPL bbl photorejuvenation evidence for Rosacea erythematotelangiectatic

B 56.1 / 100 Supported 22 RCT/meta · 12 clinical/observational · 15 case · 128 total
Good evidence · positive conclusion

There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Includes meta-analysis/SR Median year 2019 Last 5 years 41% Positive results 55% Negative results 6 Korea/Asia 7

Known in Korea as

IPLLPL튠라이트바디 BBL

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Drugs with meibomian gland expression alone versus combined with intense pulsed light in ocular rosacea: a randomised controlled study. Eye (London, England) · 2025 · PMID 41455826

Abstract summary (English) OBJECTIVES: To determine the effects of intense pulsed light (IPL) combined with meibomian gland expression (MGX) and topical medication on ocular rosacea and assess glutathione peroxidases (GPxs) change in the meibum after IPL treatments. METHODS: Ninety-six eyes of 48 participants with ocular rosacea were randomly assigned to either MGX with erythromycin eye ointment alone (control group) or the combination with...

Journal Article, Randomized Controlled Trial

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tier1 Laser and energy-based devices for treating rosacea - a systematic review and network meta-analysis. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025 · PMID 41273013

Abstract summary (English) BACKGROUND AND OBJECTIVES: Rosacea is a chronic inflammatory condition affecting the central face. While laser and energy-based devices (EBDs) are commonly used for managing vascular symptoms, comprehensive comparisons between systems are limited. This study aims to evaluate and compare the efficacy and safety of lasers and EBDs for rosacea through a systematic review and network meta-analysis (NMA).

Journal Article, Network Meta-Analysis, Systematic Review

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tier1 Effect of Intense Pulsed Light Combined With 3% Tranexamic Acid for Facial Erythema Associated With Acne Vulgaris and Rosacea. Lasers in surgery and medicine · 2025 · PMID 40518702

Abstract summary (English) BACKGROUND: Current treatment options for facial erythema associated with acne and rosacea include oral and topical treatments. Physical modalities are also commonly used recently. Combination therapy usually works better than a single therapy.

Journal Article, Randomized Controlled Trial

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tier1 Meta-Analysis of the Efficacy of Intense Pulsed Light and Pulsed-Dye Laser Therapy in the Management of Rosacea. Journal of cosmetic dermatology · 2024 · PMID 39240125

Abstract summary (English) OBJECTIVE: The primary aim of this systematic review and meta-analysis was to synthesize and compare the clinical efficacy of intense pulsed light (IPL) and pulsed-dye laser (PDL) therapies for the management of rosacea. METHODS: The literatures were searched in the Web of Science, PubMed, Embase, and Cochrane Library databases to identify relevant studies investigating the use of IPL and PDL for the treatment of...

Comparative Study, Journal Article, Meta-Analysis, Systematic Review

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tier1 Efficacy and safety of intense pulsed light in rosacea: A systematic review. Indian journal of dermatology, venereology and leprology · 2024 · PMID 39152889

Abstract summary (English) Background Rosacea is a chronic inflammatory disease of the skin characterised by facial erythema, oedema, telangiectasias, papules, pustules and nodules. There is a paucity of effective therapeutic modalities for the management of rosacea. Intense Pulsed Light (IPL), a modality in which flash lamps installed in an optical treatment device (head or tip) with mirrors to reflect light, has in recent times gained...

Journal Article, Systematic Review

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tier1 Efficacy and safety comparison between pulsed dye laser and intense pulsed light configured with different wavelength bands in treating erythematotelangiectatic rosacea. Lasers in medical science · 2024 · PMID 38822948

Abstract summary (English) Previous clinical studies have shown that pulsed dye laser (PDL) and intense pulsed light (IPL) are effective for treating erythematotelangiectatic rosacea(ETR). This article aims to compare the efficacy and safety of PDL and IPL at three different wavelength bands (broad-band, single-narrow-band, and dual-narrow-band) in treating ETR. Sixty subjects with ETR were randomly categorized into four groups and received...

Journal Article, Randomized Controlled Trial, Comparative Study

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tier1 Treatment of ocular rosacea: a systematic review. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2024 · PMID 38243868

Abstract summary (English) Rosacea is a common chronic skin disease distributed primarily around the central face. Ocular manifestations of rosacea are poorly studied, and estimates of prevalence vary widely, ranging from 6% to 72% in the rosacea population. Treatment options for ocular rosacea include lid hygiene, topical and oral antibiotics, cyclosporine ophthalmic emulsion, oral vitamin A derivatives, and intense pulsed light; however, a...

Systematic Review, Journal Article

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tier1 Comparison of Different Anti-Demodex Strategies: A Systematic Review and Meta-Analysis. Dermatology (Basel, Switzerland) · 2022 · PMID 36310014

Abstract summary (English) BACKGROUND: Demodex mites are related to some inflammatory diseases such as rosacea and blepharitis and could be harmful in patients with immunodeficiency or immunosuppression, especially notable in patients using biologic like dupilumab. In order to have an objective observation of different anti-Demodex strategies, we conducted this study, based on interventional clinical evidence with quantified Demodex mite...

Systematic Review, Meta-Analysis, Journal Article

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tier1 Intense pulsed light improves signs and symptoms of dry eye disease due to meibomian gland dysfunction: A randomized controlled study. PloS one · 2022 · PMID 35737696

Abstract summary (English) PURPOSE: To compare the safety and efficacy of intense pulsed light (IPL) followed by meibomian gland expression (MGX), against monotherapy of MGX. METHODS: Patients with moderate to severe meibomian gland dysfunction (MGD) were 1:1 randomized to 4 sessions of intense pulse light + MGX at 2-week intervals, or 4 sessions of Sham + MGX at 2-week intervals. Both patients and examiners were blinded to the allocation.

Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

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tier1 Photodynamic therapy in the treatment of rosacea: A systematic review. Photodiagnosis and photodynamic therapy · 2022 · PMID 35470124

Abstract summary (English) OBJECTIVE: To systematically review the efficacy of photodynamic therapy (PDT) in the treatment of rosacea. METHODS: PubMed, Embase, and Cochrane Library databases were searched for articles published by February 5, 2022, using "photodynamic therapy" and "rosacea" as the keywords. RESULTS: Nine studies were included in the review.

Journal Article, Systematic Review

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Suggested interpretation

Strong evidence base

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