GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Pigment · Solar lentigo / sunspot

Fractional picosecond resurfacing evidence for Solar lentigo / sunspot

B 56.9 / 100 Insufficient 2 RCT/meta · 1 clinical/observational · 1 case · 4 total
Insufficient evidence

There is not yet enough PubMed evidence for this combination. The procedure exists, but research on this indication may be scarce.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Includes meta-analysis/SR Median year 2024 Last 5 years 75% Positive results 50% Korea/Asia 1

Known in Korea as

피코프락셀

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Treatment of Solar Lentigines: A Systematic Review of Clinical Trials. Journal of cosmetic dermatology · 2025 · PMID 40145274

Abstract summary (English) BACKGROUND: Solar lentigines, resulting from chronic UV exposure, are early signs of photoaging and can significantly affect individuals. AIMS: This systematic review evaluates the efficacy, safety, and tolerability of treatments for solar lentigines in light of a lack of conclusive evidence regarding optimal therapy options. METHODS: A systematic search of PubMed/Medline, EMBASE, Cochrane Library, and...

Systematic Review, Journal Article

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tier1 Exploring Fractional Pigment Toning: A Novel Approach for Treating Benign Pigmented Lesions in Asian Patients With Fitzpatrick Skin Types III-V. Lasers in surgery and medicine · 2024 · PMID 39075754

Abstract summary (English) BACKGROUND/OBJECTIVE: Laser therapy has emerged as a widely favored treatment option for solar lentigines (SL). However, a significant challenge associated with this treatment, particularly among individuals with darker skin tones, is the notable risk of postinflammatory hyperpigmentation (PIH) induction. In response to these concerns, the authors conducted a prospective, self-controlled study to comprehensively...

Journal Article, Randomized Controlled Trial

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tier2 Sound levels and safety in cosmetic laser surgery. Lasers in surgery and medicine · 2019 · PMID 30706964

Abstract summary (English) OBJECTIVES: Measure the sound levels produced by various lasers commonly used during routine outpatient cosmetic surgery to determine whether or not their use exceeds exposure levels set forth by the US National Institute for Occupational Safety and Health (NIOSH) and the US Occupational Safety and Health Administration (OSHA). MATERIALS AND METHODS: Using two different meters, the sound levels of lasers commonly...

Journal Article, Observational Study

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tier3 Efficacy of 532-nm Nd: YAG Fractional Picosecond Laser with 9 mm High Coverage Handpiece Micro Lens Array in the Treatment of Facial Partial Unilateral Lentiginosis: A Case Report. Journal of lasers in medical sciences · 2024 · PMID 39188929

Abstract summary (English) Introduction: Facial partial unilateral lentiginosis (PUL) is an infrequent skin pigmentation disorder characterized by multiple lentigines. Despite the availability of various treatment modalities, there is no standard treatment for PUL. This study reports a successful treatment of facial PUL in a female patient using a novel 532-nm Nd:YAG fractional picosecond laser (FPL).

Case Reports, Journal Article

View on PubMed

Suggested interpretation

Limited evidence

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