Fractional laser resurfacing evidence for Hypertrophic scar / keloid

Abstract summary (English) BACKGROUND: This study aims to systematically evaluate the efficacy and safety of fractional CO₂ laser therapy combined with triamcinolone acetonide (TA) injection for hypertrophic scar (HS). MATERIALS AND METHODS: Randomized controlled trials (RCTs) investigating the combination therapy of fractional CO₂ laser and TA injection for HS were identified through systematic searches of PubMed, Embase, Cochrane...

Journal Article, Systematic Review

Abstract summary (English) Purpose Burn injuries often result in hypertrophic scars, causing functional impairment and aesthetic concerns. Laser therapies, including pulsed dye laser (PDL) and ablative fractional CO2 laser (AFCL), have emerged as promising treatments. This study aimed to evaluate the efficacy and safety of PDL, AFCL, and their combination in treating burn scars through a systematic review and network meta-analysis.

Journal Article, Systematic Review, Network Meta-Analysis

Abstract summary (English) To evaluate the effectiveness of fractional CO2 laser monotherapy in treating HS and keloids compared to other laser treatments. A systematic review and meta-analysis were conducted by searching Medline, PubMed, and Cochrane databases for studies comparing fractional CO2 laser therapy to other laser treatments for hypertrophic scars and keloids. Data were analyzed using IBM SPSS Statistics, assessing Vancouver Scar...

Journal Article, Systematic Review, Meta-Analysis

Abstract summary (English) Hypertrophic scar (HTS) remains a comorbidity of burn injury, often requiring split-thickness skin grafting (STSG) and resulting in symptomatic HTS at grafted sites and STSG donor sites (DS). Literature supports the use of ablative fractional CO2 laser (FLSR) to treat HTS, however many trials lack control sites and tissue-level examinations. Given the widespread adoption of FLSR for HTS, delegation of non-treated...

Journal Article, Randomized Controlled Trial

Abstract summary (English) Scar formation is a common outcome of tissue injury, manifesting as atrophic, hypertrophic, and keloid scars, which can significantly impact quality of life. Laser therapy has emerged as a promising treatment modality for scars, encompassing ablative and non-ablative approaches, yet there are gaps in understanding their comparative efficacy, safety, and patient satisfaction. This study aims to comprehensively review...

Journal Article, Systematic Review, Comparative Study

Abstract summary (English) Burn scars are significant consequence of thermal burn injuries, causing cosmetic concerns and potentially leading to symptomatic discomfort or functional limitations; therefore, continuous adoption of novel methods is warranted to improve outcomes. This study aims to assess and compare the effectiveness, safety, and satisfaction of fractional CO2 laser treatment alone versus its combination with oral pentoxifylline...

Journal Article, Randomized Controlled Trial

Abstract summary (English) Melasma is a chronic hyperpigmentary disorder characterized by light-brown to bluish-gray patches. No single treatment is universally efficacious. Thus, a combination treatment should be applied.

Journal Article, Systematic Review, Meta-Analysis, Comparative Study

Abstract summary (English) The aim of this study is to compare pulsed dye laser (PDL) and ablative fractional lasers (CO2, Erbium-YAG) in the treatment of hypertrophic scars in a systematic review. Databases including Web of Science, Science Direct, Google Scholar and PubMed were searched for clinical trials up to December 1, 2022; focusing on the role of ablative fractional lasers and pulsed dye lasers in treating hypertrophic scars, using...

Journal Article, Systematic Review, Comparative Study

Abstract summary (English) Hypertrophic scars (HTSs) are the result of an abnormal healing process resulting from burns and other severe traumas. The symptoms of that condition include skin irritation, discomfort, and itching. This study aimed to assess the efficacy of fractional carbon dioxide (CO₂) laser therapy alone or with triamcinolone or 5-fluorouracil (FU) in the treatment of early post-burn hypertrophic scars (HTSs) that...

Comparative Study, Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Hypertrophic scars (HTSs) result from aberrant wound healing processes, leading to raised, thickened tissue with functional discomfort and cosmetic concerns. Current treatments, including corticosteroid injections and laser therapy, have limitations. Stromal vascular fraction (SVF) therapy and CO2 laser treatment offer promising avenues, with SVF therapy showing regenerative potential and CO2 laser...

Journal Article, Systematic Review, Meta-Analysis