Exosome topical or injection evidence for Post-laser recovery

Abstract summary (English) Clinically, wound healing remains a significant challenge, particularly in the management of chronic wounds such as diabetic foot ulcers. The comparative effectiveness of various non-coding RNA (ncRNA) categories has not yet been thoroughly assessed, even though exosomal ncRNA has become a promising therapeutic molecule. To assess the effectiveness and safety of exosomal ncRNA in wound healing within preclinical...

Journal Article, Systematic Review, Meta-Analysis

Abstract summary (English) Stem cell-derived and plant-derived exosomes are emerging as promising therapeutic agents in cutaneous repair, regeneration, and rejuvenation. They facilitate wound healing and skin revitalization through multifaceted mechanisms, including immunomodulation, promotion of cellular differentiation, and stimulation of angiogenesis. Additionally, their ability to modulate collagen production and remodeling underscores...

Journal Article, Review, Systematic Review

Abstract summary (English) Exosome therapy represents an emerging regenerative medicine approach for optimizing wound healing and reducing scarring. Extensive pre-clinical research on human placental mesenchymal stem cell-derived exosomes (hpMSC-exosomes) demonstrates significant therapeutic potential in aesthetic and reconstructive surgery applications. Despite compelling preclinical evidence supporting the efficacy of exosomes in wound...

Journal Article, Systematic Review, Meta-Analysis

Abstract summary (English) Exosomes are nanoscale extracellular vesicles that facilitate intercellular communication by transporting regulatory molecules, such as microRNAs, proteins, and lipids. Acting as "software updates" for cells, exosomes influence gene expression and cellular behavior without altering the genetic code. Their emerging roles in tissue repair, immune modulation, and age-related rejuvenation have positioned them as...

Journal Article, Systematic Review

Abstract summary (English) The aim of this systematic review is to systematically compile evidence from the past 5 years on bioengineering and regenerative medicine approaches targeting the DFU immune microenvironment and to evaluate these findings from a translational perspective to inform clinical applications. This systematic review, conducted according to PRISMA 2020 guidelines, summarised evidence from 34 studies published between 2020...

Journal Article, Systematic Review, Review

Abstract summary (English) OBJECTIVE: The objective of the study is to systematically evaluate the efficacy and mechanisms of action of stem cell-derived exosomes from various sources (including adipose tissue [AD-MSCs] and bone marrow [BM-MSCs]) in treating diabetic foot ulcers (DFUs) based on preclinical evidence. METHOD: A computerized search was performed across multiple databases including PubMed, CBM, Web of Science, Embase, Wanfang,...

Journal Article, Meta-Analysis, Systematic Review, Review

Abstract summary (English) INTRODUCTION: Atrophic scars, caused by insufficient collagen deposition and ECM production during wound healing, significantly affect patients' quality of life. Conventional treatments often fail to achieve complete skin regeneration, prompting interest in regenerative medicine. This review evaluates the efficacy and safety of emerging regenerative therapies, including extracellular vesicles, conditioned media,...

Journal Article, Systematic Review, Review

Abstract summary (English) Corneal scarring remains a leading cause of visual impairment and preventable blindness worldwide, particularly where access to corneal transplantation is limited. Over the past decade, significant advances have been made in nonsurgical therapies aimed at preventing or mitigating corneal fibrosis. This systematic review summarizes emerging nonsurgical interventions, including synthetic drugs, plant- and...

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: Diabetic foot ulcers (DFUs), which have high rates of recurrence, amputation, and death, are a significant complication in the therapy of diabetes. Chronic inflammation, vascular dysfunction, and peripheral neuropathy are the results of their etiology, which includes dysregulated glucose homeostasis. These elements contribute to the poor clinical outcomes of DFUs and their complexity.

Journal Article, Randomized Controlled Trial

Abstract summary (English) AIM: Exosomes, small endosome-derived membrane vesicles, have shown significant potential as wound healing therapies. However, translating experimental research into commercially available treatments remains a challenge. OBJECTIVES: This systematic review and meta-analysis provide a comprehensive evaluation of the current research on exosome-based wound healing therapies.

Journal Article, Systematic Review, Meta-Analysis