Exosome topical or injection evidence for Androgenetic alopecia - female

Abstract summary (English) Alopecia areata (AA) is an autoimmune-mediated nonscarring alopecia with limited therapeutic options and frequent relapses. Exosomes, nanosized extracellular vesicles secreted by various cell types, have recently emerged as potential regenerative and immunomodulatory therapies. The aim of the study is to review the clinical and preclinical evidence regarding the efficacy and safety of EV-based therapies for alopecia...

Journal Article, Systematic Review

Abstract summary (English) Lichen planopilaris (LPP), frontal fibrosing alopecia (FFA), and discoid lupus erythematosus (DLE) are lymphocytic cicatricial alopecias causing irreversible follicular loss. Procedural therapies have been proposed to control inflammation, remodel scarred tissue, and, occasionally, promote hair regrowth. We performed a PRISMA-guided systematic review of PubMed/Medline, Ovid Embase, and Scopus through July 28, 2025,...

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: Exosomes are small extracellular vesicles with potential roles in modulating the hair growth cycle and are an emerging therapy for patients with alopecia. In recent years, researchers have made significant progress in deciphering the network of cellular interactions and signaling pathways mediated by the transfer of exosomes. This has opened the door to a wide range of potential therapeutic applications...

Systematic Review, Journal Article

Abstract summary (English) BACKGROUND: Hair graying is an age-associated condition primarily caused by the depletion and dysfunction of melanocyte stem cells within hair follicles. Emerging regenerative strategies, including exosome-based therapies, offer the potential to restore pigmentation by targeting underlying cellular mechanisms. OBJECTIVE: To investigate the clinical outcomes and correlates of hair repigmentation following...

Journal Article, Observational Study

Abstract summary (English) Thinning hair affects the quality of life of affected men and women but has limited treatment options. A novel technology refines exosomes from stem cells to create a concentrated complex that is quickly absorbed into the scalp to deliver growth factors, peptides, coenzymes, minerals, amino acids, and vitamins (Exosome Regenerative Complex+®. BENEV, Inc.; Mission Viejo, CA).

Clinical Trial, Journal Article

Abstract summary (English) BACKGROUND: The use of micrografts (MCGs) containing human follicle mesenchymal stem cells (HF-MSCs) is a hair loss (HL) treatment that needs to be standardized as seems to have promising effects on hair regrowth (HR-G) also thanks to the presence of extracellular vesicles (EVs). OBJECTIVES: The study aims to report both the in vivo results, obtained in patients affected by androgenic alopecia (AGA) treated using...

Journal Article, Multicenter Study, Observational Study

Abstract summary (English) BACKGROUND: Regenerative therapies have emerged in recent years. In particular, their utility in managing androgenetic alopecia-the most prevalent hair loss condition worldwide, affecting up to half of adults-is an active area of research. Navigating this space can be challenging for physicians due to widespread commercialization, lack of high-quality evidence, and an evolving regulatory landscape.

Journal Article, Review

Abstract summary (English) BACKGROUND: Exosomes are nanoscale vesicles derived from various cell types and tissues that have many potential applications, generating great interest from researchers. One particularly intriguing application of exosomes is their use as a direct therapeutic for aesthetic indications. Several studies and case reports have explored the impact of exosomes for numerous cosmetic concerns but a consensus on the outcomes...

Journal Article, Review

Abstract summary (English) BACKGROUND: The regenerative properties of exosomes make them especially appealing to treat skin and hair diseases. Preclinical studies suggest that exosomes may fuel hair growth by stimulating dermal papilla cells, activating hair follicle stem cells, and promoting angiogenesis. However, very limited data are available on the safety and efficacy of exosome use in human subjects.

Journal Article, Review

Abstract summary (English) Exosomes are lipid bilayer vesicles, 30-200 nm in diameter, that are produced by cells and play essential roles in cell-cell communication. Exosomes have been studied in several medical fields including dermatology. Hair loss, a major disorder that affects people and sometimes causes mental stress, urgently requires more effective treatment.

Journal Article, Review