GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Body / Fat · Submental fat

Cryolipolysis body contouring evidence for Submental fat

B 51.9 / 100 Supported 1 RCT/meta · 3 clinical/observational · 1 case · 17 total
Good evidence · positive conclusion

There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Includes meta-analysis/SR Median year 2018 Last 5 years 35% Positive results 82%

Known in Korea as

쿨스컬프팅젤틱 쿨슬리밍

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Cryolipolysis for Submental Fat Reduction: A Systematic Review and Meta-Analysis. Facial plastic surgery : FPS · 2025 · PMID 40473257

Abstract summary (English) Submental fat can be addressed using both surgical and nonsurgical techniques. Cryolipolysis is a noninvasive treatment that uses cold temperatures to trigger apoptosis in adipose tissue.This study aims to evaluate the efficacy and safety of cryolipolysis for submental fat reduction, specifically analyzing changes in submental fat thickness and volume. It is hypothesized that cryolipolysis leads to measurable...

Journal Article, Systematic Review, Meta-Analysis

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tier2 Cryolipolysis for local fat reduction in adults from Brazil: A single-arm intervention study. Journal of cosmetic dermatology · 2020 · PMID 32281283

Abstract summary (English) BACKGROUND: Localized fat is a matter of great concern among individuals from today's society. Cryolipolysis is a noninvasive technique that have shown great results in reducing localized fat. AIMS: To analyze the efficacy of cryoplipolysis on visible local fat reduction in submental region, arms, or male breast (pseudogynecomastia) in Brazilian subjects, and to assess possible factors associated with treatment...

Clinical Trial, Journal Article

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tier2 Safety and Efficacy of Bilateral Submental Cryolipolysis With Quantified 3-Dimensional Imaging of Fat Reduction and Skin Tightening. JAMA facial plastic surgery · 2017 · PMID 28426847

Abstract summary (English) IMPORTANCE: Cryolipolysis is a popular, well-tolerated nonsurgical procedure that uses controlled cooling to selectively destroy fat cells. Central submental cryolipolysis has been reported to be safe and effective, but many patients would benefit from extending this treatment over the entire submental region. OBJECTIVE: To investigate the safety and efficacy of cryolipolysis for reduction of lateral and central...

Clinical Trial, Journal Article

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tier2 Safety and efficacy of cryolipolysis for non-invasive reduction of submental fat. Lasers in surgery and medicine · 2015 · PMID 26607045

Abstract summary (English) BACKGROUND AND OBJECTIVES: Cryolipolysis has previously received FDA clearance for fat reduction in the abdomen, flanks, and thighs. There is also interest in small volume fat reduction for areas such as the chin, knees, and axilla. This article reports the results of a cryolipolysis pivotal IDE study for reduction of submental fullness.

Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't

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tier0_review Cryolipolysis for the treatment of submental fat: Review of the literature. Journal of cosmetic dermatology · 2018 · PMID 29345049

Abstract summary (English) BACKGROUND: Submental fat accumulation is a common cosmetic concern. Cryolipolysis utilizes noninvasive cooling to lyse adipocytes. A cryolipolysis device was recently approved for treatment of submental fat.

Journal Article, Review

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tier0_review Noninvasive approach to treatment of submental fullness. Seminars in cutaneous medicine and surgery · 2017 · PMID 29224033

Abstract summary (English) A recent survey done by the American Society for Dermatologic Surgery indicated that 67% of respondents were bothered by "excess fat under the chin/neck." Accumulation of fat in the preplatysmal compartment of the neck is a common cause for fullness in the submental area. In the past, surgical liposuction was the only option to remove fat in the submental area. Although effective, liposuction does have risks and...

Journal Article, Review

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tier0_review Neck Contouring and Treatment of Submental Adiposity. Journal of drugs in dermatology : JDD · 2017 · PMID 28095533

Abstract summary (English) There have been many recent and significant innovations to the cosmetic physician's repertoire for addressing excess submental fat and improving patients' neck contour. These new techniques include submental cryolipolysis, injectable chemical lipolysis, percutaneous radiofrequency, laser techniques, and liposuction with or without laser or power assistance. These modalities range from completely non-invasive to...

Journal Article, Review

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tier0_review ATX-101 (deoxycholic acid injection) for reduction of submental fat. Expert review of clinical pharmacology · 2016 · PMID 27457304

Abstract summary (English) INTRODUCTION: The shape and contour of the chin and neck play an important role in facial esthetics. As such, excess fat within the submental area (double chin) can negatively affect facial esthetics and body image. Common treatments for submental contouring include invasive procedures such as surgical rejuvenation and targeted liposuction.

Journal Article, Review

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tier0_review Neck Rejuvenation Using a Combination Approach: Our Experience and a Review of the Literature. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2016 · PMID 27128251

Abstract summary (English) BACKGROUND: Aging of the neck is characterized by changes that include skin dyspigmentation, laxity, rhytides, loss of the mandibular contour, widening of the cervicomental angle, accumulation of submental fat, volume loss and prominence of the platysmal bands. Many cosmetic options exist to address these changes individually, but little literature exists about the safety and efficacy of combining such procedures...

Journal Article, Review

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tier_other "A Systematic Review of Injectable Lipolytic agents for Non-Submental Fat Reduction". Plastic and reconstructive surgery · 2025 · PMID 41296813

Abstract summary (English) INTRODUCTION: Injectable lipolytic agents have gained popularity as a non-invasive approach to localized fat reduction. While deoxycholic acid (DCA) remains the only FDA-approved agent for submental fat reduction, its application for non-submental regions is an emerging area of interest. This systematic review evaluates existing literature on injectable lipolytic agents beyond the submental region.

Journal Article

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Suggested interpretation

Limited evidence

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