Botulinum toxin a evidence for Platysmal band

Abstract summary (English) BACKGROUND: Repetitive contractions of the platysma muscle may result in vertical neck bands that blunt the jawline (i.e., platysma prominence [PP]). We report patient-reported outcomes (PROs) from a phase 2 study evaluating onabotulinumtoxinA (onabotA) for moderate or severe PP. METHODS: Subjects were randomized 1:1:1 to onabotA dose 1 (26 U, 31 U, or 36 U), onabotA dose 2 (52 U, 62 U, or 72 U), or placebo.

Journal Article, Randomized Controlled Trial, Clinical Trial, Phase II, Multicenter Study

Abstract summary (English) BACKGROUND: Platysma prominence (PP) is a common aesthetic concern associated with aging, leading to visible neck bands and loss of jawline definition. OnabotulinumtoxinA has emerged as a minimally invasive treatment; however, data from randomized controlled trials (RCTs) remain fragmented. AIMS: To systematically evaluate the efficacy and safety of onabotulinumtoxinA for treating moderate to severe PP through...

Journal Article, Systematic Review, Meta-Analysis, Review

Abstract summary (English) INTRODUCTION: The platysma muscle influences lower face and neck aesthetics and expression. Aging can lead to platysma prominence (PP), manifesting as visible neck bands that affect appearance and well-being. Although surgical treatments exist, they are invasive and carry notable risks.

Journal Article, Systematic Review, Meta-Analysis

Abstract summary (English) BACKGROUND: Platysma prominence (PP) describes the noticeable appearance of the platysma muscle upon contraction, causing a less defined jawline contour and vertical neck bands. OBJECTIVES: The objective of this study was to assess the safety and efficacy of onabotulinumtoxinA for improvement of PP in adults. METHODS: Participants with moderate to severe (Grade 3 to 4) PP at maximum contraction received...

Journal Article, Randomized Controlled Trial, Clinical Trial, Phase III

Abstract summary (English) BACKGROUND: Platysma prominence (PP) refers to the undesirable effects that may occur with platysma muscle contraction. OBJECTIVE: Evaluate safety and efficacy of onabotulinumtoxinA for improving Moderate (Grade 3) to Severe (Grade 4) PP in adults. METHODS: Participants were randomized 1:1 to receive a total dose of onabotulinumtoxinA 26, 31, or 36 U or placebo on Day 1 and monitored for 120 days.

Journal Article, Randomized Controlled Trial, Clinical Trial, Phase III

Abstract summary (English) BACKGROUND: With aging, repetitive contraction of the platysma leads to an increase in platysma prominence (PP), characterized by the accentuation of vertical neck bands and blunting of the jawline contour. METHODS: This multicenter, double-blind, phase 2 study evaluated onabotulinumtoxinA treatment in adults with moderate to severe PP. Participants were randomized to receive 1 treatment of onabotulinumtoxinA low...

Journal Article, Randomized Controlled Trial, Clinical Trial, Phase II, Multicenter Study

Abstract summary (English) AbobotulinumtoxinA (aboBoNT-A) has been used for various cosmetic purposes, including minimization of moderate to severe lines, or other cosmetic indications, in the face and neck. We carried out a systematic review to identify all relevant evidence on the treatment approaches and outcomes of aboBoNT-A as a cosmetic treatment of the middle and lower areas of the face, and the neck. Embase, MEDLINE, Cochrane Library,...

Journal Article, Research Support, Non-U.S. Gov't, Systematic Review

Abstract summary (English) BACKGROUND: Platysma bands are characteristic of an aging neck. Resection and plication of the platysma muscle is the basis of treatment. However, unfavorable surgical outcomes and improved understanding of platysma band etiology have shifted treatment towards nonsurgical rejuvenation.

Journal Article, Systematic Review

Abstract summary (English) INTRODUCTION: Botulinum toxin injections are an effective, well-established treatment to manage synkinesis secondary to chronic facial palsy, but they entail painful injections at multiple sites on the face up to four times per year. Cutaneous cooling has long been recognised to provide an analgesic effect for cutaneous procedures, but evidence to date has been anecdotal or weak. This randomised controlled trial...

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: The platysma muscle plays a pivotal role in the formation of vertical neck bands and contributes to lower facial descent, making it a prime target for botulinum toxin type A (BoNT-A) in aesthetic neck rejuvenation. Conventional protocols typically involve injecting across the entire muscle, necessitating a high number of injection points and larger total doses, which may increase the risk of bruising,...

Journal Article, Comparative Study