GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Hyperhidrosis · Craniofacial hyperhidrosis

Botulinum toxin a evidence for Craniofacial hyperhidrosis

C 47.0 / 100 Supported 3 RCT/meta · 1 clinical/observational · 6 case · 17 total
Early-stage evidence

This is an early evidence stage based mainly on observational studies and case reports. Use it as supplementary reference, and follow your doctor's judgment for treatment decisions.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Includes meta-analysis/SR Median year 2018 Last 5 years 35% Positive results 47% Negative results 1

Known in Korea as

톡신보톡스제오민디스포트코어톡스주름 보톡스다한증 보톡스디자인 보톡스사각턱 보톡스얼굴전체 톡신

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Botulinum Toxin for Scalp Conditions: A Systematic Review. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2023 · PMID 37556465

Abstract summary (English) BACKGROUND: Many reports have described the use of botulinum toxin (BTX) in the treatment of scalp conditions, but no studies have synthesized these collective findings. OBJECTIVE: We conducted a systematic review to summarize the scalp conditions for which treatment with BTX has been described. METHODS: We searched PubMed/MEDLINE and Scopus for articles in English published before November 1, 2022, using the...

Systematic Review, Journal Article

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tier1 Postmenopausal craniofacial hyperhidrosis treated with botulinum toxin type B. The Journal of dermatology · 2019 · PMID 31373068

Abstract summary (English) Hyperhidrosis can seriously impair patients' quality of life. Medical history, including heredity and hyperhidrosis during youth, as well as current age and time elapsed since menopause, is important to consider when distinguishing between postmenopausal hyperhidrosis and vasomotor symptoms to enable adequate treatment. This report concerns a subgroup of eight postmenopausal patients participating in a randomized...

Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial

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tier1 Treatment of Primary Craniofacial Hyperhidrosis: A Systematic Review. American journal of clinical dermatology · 2015 · PMID 26055729

Abstract summary (English) BACKGROUND: Primary craniofacial hyperhidrosis (CH) can have a profoundly negative impact on quality of life. No comprehensive review of its management exists. OBJECTIVE: The objective of this review is to present the best clinical evidence to guide CH management.

Journal Article, Systematic Review

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tier2 Longitudinal Assessment of Facial Hyperhidrosis Management: Evaluating the Utility and Quality of Life Improvements following Botulinum Toxin Injection. Toxins · 2024 · PMID 38276535

Abstract summary (English) Facial hyperhidrosis is a debilitating condition that can severely impact the quality of life. This study aimed to assess the long-term utility of Botulinum toxin type A therapy (BTA) for facial hyperhidrosis and its impact on quality of life over a one-year period. Conducted at the Pius Brinzeu Clinical Emergency Hospital in Timisoara, Romania, this longitudinal observational study involved 77 adult patients with...

Observational Study, Journal Article

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tier0_review Efficacy and Safety of Botulinum Toxin B in Focal Hyperhidrosis: A Narrative Review. Toxins · 2023 · PMID 36828461

Abstract summary (English) Botulinum toxin type B (BoNT-B), known as Myobloc® in the United States and as Neurobloc® in Europe, is a new therapeutically available serotype among the botulinum toxin family. During the last years several data have been reported in literature investigating its efficacy and safety, as well as defining the dosing and application regiments of BoNT-B in the treatment of hyperhidrosis. Moreover,...

Journal Article, Review

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tier0_review Intradermal Botulinum Toxin A Injection Versus Topical 2% Glycopyrrolate for the Treatment of Primary Facial Hyperhidrosis: A Pilot Study and Review of Literature. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2022 · PMID 35917265

Abstract summary (English) BACKGROUND: Facial hyperhidrosis (HH), a common problem with both cosmetic and psychological impact, interferes with quality of life. Wide range of treatment options is available for HH. Finding the most effective and yet a safe, tolerable option is the main target.

Journal Article, Review

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tier0_review Botulinum toxin: Pharmacology and injectable administration for the treatment of primary hyperhidrosis. Journal of the American Academy of Dermatology · 2019 · PMID 31811879

Abstract summary (English) Hyperhidrosis is a dermatological condition defined by excessive sweating beyond thermoregulatory needs with significant effects on patients' quality of life. Hyperhidrosis is categorized as primary or secondary: primary hyperhidrosis is mostly focal and idiopathic, whereas secondary hyperhidrosis is commonly generalized and caused by an underlying medical condition or use of medications. Various surgical and...

Journal Article, Review

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tier0_review Hyperhidrosis: Management Options. American family physician · 2018 · PMID 30215934

Abstract summary (English) Hyperhidrosis is excessive sweating that affects patients' quality of life, resulting in social and work impairment and emotional distress. Primary hyperhidrosis is bilaterally symmetric, focal, excessive sweating of the axillae, palms, soles, or craniofacial region not caused by other underlying conditions. Secondary hyperhidrosis may be focal or generalized, and is caused by an underlying medical condition or...

Journal Article, Review

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tier0_review [Usefulness of bilateral sympathectomy using video-assisted thorascopic surgery in the treatment of essential hyperhidrosis]. Actas dermo-sifiliograficas · 2008 · PMID 18682164

Abstract summary (English) Essential, idiopathic, or primary hyperhidrosis is defined as excessive sweating in certain areas of the body due to factors unrelated to other disease. Clinical presentation can be categorized as palmar, plantar, axillary, or craniofacial. Medical treatment (aluminium salts, iontophoresis, anticholinergic drugs, and alpha2-agonists) is of questionable effectiveness.

English Abstract, Journal Article, Review

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tier0_review Surgical approaches and techniques in the management of severe hyperhidrosis. Thoracic surgery clinics · 2008 · PMID 18557590

Abstract summary (English) Thoracoscopy has afforded a huge advance for upper thoracic sympathetic procedures compared with prior open procedures. Different clinical syndromes of hyperhidrosis exist and require different forms of treatment. The classic severe palmoplantar pattern of hyperhidrosis will not respond effectively in the long term to any nonoperative treatment and requires sympathectomy for cure.

Journal Article, Review

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Suggested interpretation

Limited evidence

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