GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Acne / Scar / Texture · Active inflammatory acne

Bipolar multipolar RF contouring evidence for Active inflammatory acne

B 50.6 / 100 Supported 4 RCT/meta · 4 clinical/observational · 0 case · 13 total
Good evidence · positive conclusion

There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Median year 2014 Last 5 years 8% Positive results 77% Negative results 1 Korea/Asia 3

Known in Korea as

GPC인모드코레지튠컬트라나노필로티세예핏-S써니리프팅코어스컬프트리플바디바디 인모드

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Comparison between Er:YAG laser and bipolar radiofrequency combined with infrared diode laser for the treatment of acne scars: Differential expression of fibrogenetic biomolecules may be associated with differences in efficacy between ablative and non-ablative laser treatment. Lasers in surgery and medicine · 2016 · PMID 27805273

Abstract summary (English) BACKGROUND AND OBJECTIVE: Fractional Er:YAG minimizes the risk associated with skin ablation. Infrared diode laser and radiofrequency have suggested comparable improvements in acne scar. We compared the clinical efficacy of Er:YAG laser and bipolar radiofrequency combined with diode laser (BRDL) for the treatment of acne scars.

Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

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tier1 Comparison of fractional microneedling radiofrequency and bipolar radiofrequency on acne and acne scar and investigation of mechanism: comparative randomized controlled clinical trial. Archives of dermatological research · 2015 · PMID 26472097

Abstract summary (English) Fractional microneedling radiofrequency (FMR) is one of the promising methods in acne treatment. Moreover, bipolar radiofrequency (BR) generates heat thereby which induces neocollagenosis. FMR may have the potential to be a safe and effective treatment for the patients both with acne and acne scar.

Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

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tier1 Comparison of a fractional bipolar radiofrequency device and a fractional erbium-doped glass 1,550-nm device for the treatment of atrophic acne scars: a randomized split-face clinical study. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2013 · PMID 24267397

Abstract summary (English) BACKGROUND: A fractional erbium-doped glass 1,550-nm and a fractional bipolar radiofrequency (RF) device are effective in the treatment of atrophic acne scars. OBJECTIVE: To compare the clinical effectiveness and side effects of fractional bipolar RF with those of fractional erbium-doped glass in atrophic acne scars treatment. MATERIALS AND METHODS: Twenty Thai subjects with atrophic acne scars received three...

Comparative Study, Journal Article, Randomized Controlled Trial

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tier1 A comparison of intense pulsed light, combination radiofrequency and intense pulsed light, and blue light in photodynamic therapy for acne vulgaris. Journal of drugs in dermatology : JDD · 2007 · PMID 17966178

Abstract summary (English) BACKGROUND: Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is an emerging modality for the treatment of acne vulgaris. However, optimal therapeutic protocols have not been established. OBJECTIVES: To compare the efficacies of 3 different light sources for activating ALA-induced protoporphyrin IX for the treatment of acne vulgaris.

Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

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tier2 Clinical evaluation of the efficacy and safety of fractional bipolar radiofrequency for the treatment of moderate to severe acne scars. Dermatologic therapy · 2015 · PMID 26279170

Abstract summary (English) Several treatment modalities are used for the treatment of acne scars with variable results. Recent studies showed that fractional radiofrequency may be an effective treatment modality for acne scars. The objective of this study was to assess the efficacy, safety, tolerability and patient satisfaction of fractional bipolar radiofrequency (RF), the eTwo™ system (Syneron Candela Ltd., Yokneam, Israel) for treating...

Clinical Trial, Journal Article

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tier2 Evaluation of the efficacy and safety of fractional bipolar radiofrequency with high-energy strategy for treatment of acne scars in Chinese. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology · 2015 · PMID 25588035

Abstract summary (English) BACKGROUND: Fractional technology overcomes several problems of ablative lasers such as a high incidence rate of post- inflammatory hyperpigmentation (PIH). A new technology fractional radiofrequency, which induces deep dermal heating and leaves the epidermal less affected results in less adverse effect in Chinese. OBJECTIVE: To evaluate the efficacy, safety and tolerance of fractional bipolar radiofrequency (RF) in...

Clinical Trial, Journal Article

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tier2 Treatment of acne scars by fractional bipolar radiofrequency energy. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology · 2012 · PMID 22548644

Abstract summary (English) BACKGROUND/OBJECTIVE: A variety of modalities are available for the treatment of acne scars. This prospective, IRB-approved study evaluates the efficacy and tolerance of fractional bipolar RF energy in the treatment of facial acne scars. METHODS: Healthy subjects (n = 15, 13 females, aged 35.7 ± 5.6 years [mean ± SD], skin types I-V) with mild to moderate acne scars received three monthly treatments with a...

Clinical Trial, Journal Article

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tier2 Bipolar radiofrequency in the treatment of dermatologic imperfections: clinicopathological and immunohistochemical aspects. Journal of drugs in dermatology : JDD · 2007 · PMID 17941360

Abstract summary (English) BACKGROUND: Rapid progress in the technology for skin rejuvenation has allowed for shorter post-treatment times than ever before. An example of such technology is the radiofrequency (RF) device, which offers nonablative skin rejuvenation, particularly for skin tightening and wrinkle reduction. OBJECTIVE: Medical devices that emit RF energy produce a change in the electrical charges of the treated skin creating an...

Clinical Trial, Journal Article

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tier0_review Bipolar radiofrequency for facial rejuvenation. Facial plastic surgery clinics of North America · 2007 · PMID 17544931

Abstract summary (English) Combined approaches using light and radiofrequency represent an innovative approach to whole body rejuvenation. Synergistic results using combined modalities are a major advantage of this technology. In addition, by using lower levels of light energy, darker skin phenotypes can be treated with a lower risk for pigment dyschromia and scarring.

Journal Article, Review

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tier_other Therapeutic effects of a new invasive pulsed-type bipolar radiofrequency for facial erythema associated with acne vulgaris and rosacea. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology · 2021 · PMID 33650938

Abstract summary (English) Facial erythema from rosacea and acne is one of the most common problems encountered in dermatologic clinics. Effective therapeutic interventions for persistent erythema, which can cause patients frustration and psychological distress, are needed. The aim of this study was to evaluate the efficacy and safety of an invasive short pulsed-type bipolar radiofrequency device (IPBRF) for the treatment of intractable...

Journal Article

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